MEP and Neuromuscular Blocker

Gangnam Severance Hospital100 enrolled

Overview

It is important to predict the influence of the neuromuscular blocking agents on the motor evoked potential. Investigator will investigate the dose-response relationship between the degree of the neuromuscular blockade and the motor evoked potential in patients undergoing brain tumor surgery using the population approach. Investigator will investigate the influence of the other factors such as the impedence, reactance, muscel amount, and age on the motor evoked potential.

Study Type

INTERVENTIONAL

Allocation

Purpose

SUPPORTIVE_CARE

Masking

NONE

Enrollment

100

Conditions

Brain Tumor

Interventions

Arm I (MEP)DRUG

Arm I (MEP): Motor evoked potential will be measured in various degree of the neuromuscular blockade.

Eligibility

Sex: ALLMin age: 19 Years

Medical Language ↔ Plain English

Inclusion Criteria: 1\. Patients aged 19 years old or older, with American Society of Anesthesiologists Physical Status 1-3, and scheduled for elective brain tumor surgery under the monitoring of the motor evoked potential Exclusion Criteria: 1. Central or peripheral neuromuscular disease 2. Sensory or motor nerve disorder 3. Allergy to propofol, remifentanil, and rocuronium 4. Patients with pacemaker

Locations (1)

GangnamSeverance Hospital

Seoul, South Korea

Outcomes

Primary Outcomes

Amplitude of the motor evoked potential

Amplitude of the motor evoked potential will be evaluated at intraoperative 0 h from the start of the anesthetic induction.

Time frame: At intraoperative 0 hr from the start of the anesthetic induction

Secondary Outcomes

Amplitude of the motor evoked potential

Amplitude of the motor evoked potential will be evaluated at intraoperative 0 h from the opening of the dura.

Time frame: At intraoperative 0 h from the opening of the dura

Data from ClinicalTrials.gov

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