Intra-pocket Application of Tea Tree Oil Gel in the Treatment of Stage-2 Periodontitis

Alexandria University30 enrolled

Overview

This study aimed to assess clinically and biochemically the effect of intrapocket application of tea tree oil (TTO) gel adjunctive to SRP in the management of stage 2(moderate) periodontitis and to correlate the biochemical levels with clinical response.

A randomized, controlled clinical trial included thirty patients with stage 2 periodontitis. They were equally divided into two groups: Group 1 (control group) treated with scaling and root planning (SRP) alone and Group 2 (test group) managed by SRP and locally delivered 5% tea tree oil (TTO) gel.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

SINGLE

Enrollment

Conditions

Periodontitis

Interventions

Scaling and Root PlaningPROCEDURE

Supra- and sub-gingival calculus and debris were removed

Scaling and Root Planing with tea tree oilDRUG

Supra- and sub-gingival calculus and debris were removed and 5% tea tree oil was applied

Eligibility

Sex: ALLMin age: 20 YearsMax age: 40 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Patients diagnosed with stage 2,grade B periodontitis according to the 2017 World Workshop on the Classification of Periodontal and Peri-Implant Diseases and Conditions. * Patients with CAL 3-4 mm , BOP and radiographic horizontal bone loss related to the coronal third of the root (15%-33%). * Patients with no teeth loss due to periodontitis. * Patients with radiographic bone loss/age % of 0.25-1 %. * Patients who could maintain an O'Leary plaque index ≤10 proceeded into the study. Exclusion Criteria: * Patients with CAL caused by non periodontal causes. * Patients with grade C periodontitis. * Patients having any systemic disease that may affect the treatment outcomes * Smokers. * Pregnant females. * Patients receiving contraindicated medications, chemotherapy, or radiotherapy in the previous year.

Locations (1)

Faculty of Dentistry, Alexandria University

Alexandria, Egypt

Outcomes

Primary Outcomes

Probing depth

Probing depth was recorded at tested sites with graduated William's probe graduated in 1 mm increment. Readings were rounded to the nearest mm.

Time frame: up to 6 months

Clinical attachment loss

Clinical attachment loss was recorded at tested sites with graduated William's probe graduated in 1 mm increment. Readings were rounded to the nearest mm.

Time frame: up to 6 months

Bleeding on probing

Bleeding on probing was assessed at tested sites with graduated William's probe graduated in 1 mm increment, within 15 seconds after probing, using a dichotomous scoring system (+ and -) for presence or absence, respectively.

Time frame: up to 6 months

Biochemical assessment of inlammation

This involved determination of the gingival crevicular fluid (GCF) levels of matrix metalloproteinase 8 (MPP-8). A GCF sample was taken from the area showing the deepest pocket depth around the treated area.The samples were diluted in phosphate buffer saline (PBS) up to 1 mL. After waiting for 15 min, the paper points were removed, and 500 μL were centrifuged at 400 g for 4 min, then frozen at -20°C pending MMP-8 analysis using Human Matrix metalloproteinase 8/Neutrophil collagenase (MMP-8) ELISA Kit according to the manufacturer instructions.

Time frame: up to 6 months

Data from ClinicalTrials.gov

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