The purpose of this trial is to study the effect of mgso4 infusion on oxygenation and lung mechanics in morbidly obese patients undergoing bariatric surgery
Background and objectives: morbidly obese patients are characterized by a high prevalence of restrictive lung disease. Respiratory mechanics are significantly altered in obesity. These changes are exacerbated with general anesthesia .Obesity also results in reduced lung and chest wall compliance ,increased lung resistance ,reduced oxygenation.MgSo4 is promising in managing several respiratory disorders.it cause smooth muscle relaxation and reduce airflow obstruction. The objective of this trial is to study the effect of mgso4 infusion on oxygenation and lung mechanics in morbidly obese patients undergoing bariatric surgery. the following will be recorded :intraoperative oxygenation,lung mechanics,MAP,HR,EtCO2,plateau and peak airway pressure,sedation score,serum mgso4 level,change in P/F ratio and dynamic lung compliance,respiratory rate postoperative
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
PREVENTION
Masking
QUADRUPLE
Enrollment
40
mgso4 infusion will start 15 minutes after intubation , 30 mg/kg LBW of 10%mgso4 in 100 ml normal saline I.V ,over 30 minutes followed by 10 mg/kg LBW for 90 minutes
Ain Shams University Hospital
Cairo, Abassia, Egypt
Pao2
arterial oxygenation during surgery determined by Pao2
Time frame: 5 minutes after intubation to 90 minutes after starting drug infusion
Pao2/FIO2
arterial oxygenation during surgery determined by Pao2/FIO2
Time frame: 5 minutes after intubation to 90 minutes after starting drug infusion
Static lung compliance
will be calculated as:tidal volume/(plateau pressure-positive end expiratory pressure)
Time frame: 5 minutes after intubation to 90 minutes after starting drug infusion
mg sulphate level
serum mgso4 level
Time frame: One hour postoperatively
dead space
dead space will be calculated as : Vd/Vt
Time frame: 5 minutes after intubation to 90 minutes after starting drug infusion
Dynamic lung compliance
will be calculated as :tidal volume/(peak airway pressure-positive end expiratory pressure)
Time frame: 5 minutes after intubation to 90 minutes after starting drug infusion
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