This is a phase 3, open-label, multicenter, extension study to evaluate the long-term safety and efficacy of pegcetacoplan (APL-2) in subjects with geographic atrophy (GA) secondary to age-related macular degeneration (AMD) who participated in Study APL2-103 (NCT03777332) or completed the treatment at Month 24 of either Study APL2-303 (Derby, NCT03525613) or Study APL2-304 (Oaks, NCT03525600).
Study Type
INTERVENTIONAL
Allocation
NON_RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Enrollment
792
Complement (C3) Inhibitor
Incidence and severity of ocular and systemic adverse events
Time frame: Up to 36 Months
Change from baseline in the total area of GA lesion(s) in the study eye (in mm2)
The total area of GA lesion(s) in the study eye (in mm2) as assessed by FAF at Month 12, Month 24, and Month 36
Time frame: Up to 36 Months
Change from baseline in NL-BCVA score (study eye)
NL-BCVA score as assessed by Early Treatment Diabetic Retinopathy Study (ETDRS) chart at Month 12, Month 24, and Month 36
Time frame: Up to 36 Months
Change from baseline in LL-BCVA score (study eye)
LL-BCVA score as assessed by ETDRS chart at Month 12, Month 24, and Month 36
Time frame: Up to 36 Months
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