Assessment of Executive Functions After Covid-19

Saglik Bilimleri Universitesi Gazi Yasargil Training and Research Hospital128 enrolled

Overview

As it is evident that Covid-19 may have some impacts on cognition, the primary aim of this study is to investigate -if any- deficits of attention, working memory and executive functions after Covid-19.

Since Covid-19 (Coronavirus Disease-2019) was declared as a pandemic by the World Health Organization (WHO) on December 31, 2019, it is still widespread and deadly. As an ongoing pandemic, it has led to a panic and then a controlled fear in societies. In many studies, neuropsychological deficits were observed in Covid-19 patients both during the illness and after recovery. A recent study found that impairment in cognitive functions continued after recovery of Covid-19, and it was associated with peripherical inflammatory markers, such as C-Reactive Protein (CRP). CRP, as a peripherical inflammatory marker, has been proven to be inversely related to serum levels of the brain-derived neurotrophic factor (BDNF), an important neurotrophin in the growth and differentiation of neurons. In this study, attention, working memory and executive functions of Covid-19 patients at post-covid period and its relation with the severity of the disease will be investigated.

Study Type

OBSERVATIONAL

Enrollment

128

Conditions

Covid19 Cognitive Impairment

Eligibility

Sex: ALLMin age: 18 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: Covid-19 patients: * Diagnosed as Covid-19 by RT-PCR at least 60 days but not more than 90 days ago * Asymptomatic at the moment * Not having any other general medical, neurological or psychiatric conditions except Covid-19 at the time of acute infection Healthy subjects: * Not having any of Covid-19 symptoms at the testing time point * Not having any general medical, neurological or psychiatric condition Exclusion Criteria: Covid-19 patients: * Diagnosed as Covid-19 by RT-PCR less than 60 days or more than 90 days ago * Having any symptom of acute phase of Covid-19 * Having any other general medical, neurlogical or psychiatric contidions Healthy subjects: * Having any of Covid-19 symptoms at the testing time point * Having any general medical, neurological or psychiatric condition

Locations (1)

Sağlık Bilimleri Üniversitesi Gazi Yaşargil Training and Research Hospital

Diyarbakır, Turkey (Türkiye)

Outcomes

Primary Outcomes

Neuropsychological test scores

Neuropsychological test scores of Covid-19 patients in comparison with healthy control subjects

Time frame: Up to 90 days

Secondary Outcomes

Severity of the disease

Neuropsychological test score changes according to the disease severity of Covid-19 patients

Time frame: Up to 90 days

Data from ClinicalTrials.gov

This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.