Edmon (BBraun, Germany) is a portable, commercially available device for measurement of propofol in exhaled air. The study will aim at evaluating the sensitivity and specificity of such exhaled propofol values compared with plasma propofol and measures of anaesthetic and antinociceptive effect.
Elective low-back surgery patients will be induced for general intubation anesthesia with propofol and remifentanil. After induction a 20 min period of stable propofol infusion only will be established before start of surgery. The patients will be monitored for exhaled propofol, plasma propofol (blood samples), continous frontal EEG, Bispectral Index (BIS), skin conductance, estimated (computer based) concentrations of plasma and effect site propofol, and skin conductance. After start of surgery (with ongoing propofol and restart of remifentanil TCI) the monitoring will continue in order to explore these relationships further.
Study Type
INTERVENTIONAL
Allocation
NA
Purpose
DIAGNOSTIC
Masking
NONE
Enrollment
40
Exhaled air will be analyzed for propofol
Dept of Anesthesiology, Oslo University Hospital, Ullevaal
Oslo, Norway
RECRUITINGExhaled air versus plasma concentration
Time frame: per-operative
EEG recording
EEG will be recorded and compared with plasma propofol, exhaled propofol and BIS
Time frame: per-operative
Exhaled propofol 2
Exhaled propofol versus dose given, estimated plasma concentration, estimated effect site concentration
Time frame: per-operative
Nociceptive stimulation
Skin conductance versus plasma and exhaled propofol concentration
Time frame: per-operative
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