miRNA Biomarkers in Multiple Sclerosis

University of Gaziantep69 enrolled

Overview

Multiple Sclerosis (MS) characterized by demyelination and axonal degeneration is a chronic inflammatory disease of the central nervous system (CNS). Recent studies have shown that dysregulated miRNAs alter immune responses, so they may have roles basis on various genetic diseases such as MS and may be potential targets for biomarkers and new therapeutic approaches. In this study, we evaluated the dysregulation of miRNA expression levels at MS and MS stages. We also discussed the potential of these miRNAs to be biomarkers and/or therapeutic targets in MS.

Study Type

OBSERVATIONAL

Enrollment

Conditions

Multiple Sclerosis miRNA Epigenetic Biomarker

Interventions

miRNA

Eligibility

Sex: ALLMin age: 25 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * The age of 25 years and above * at least one Central Nervous System (CNS) demyelination event Exclusion Criteria: * with genetic diseases, hypertension, head trauma, neuropsychiatric disease, diabetes mellitus, hypertension, cardiac failure, hepatic failure, renal failure, Thalassemia, Sickle cell disease, iron deficiency, and B12 deficiency

Outcomes

Primary Outcomes

miRNA expression

peripheral blood miRNA expressions

Time frame: intraoperative

Data from ClinicalTrials.gov

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