Sarcopenia and Mechanical Ventilation in Older Patients Admitted Due to COVID-19

Brugmann University Hospital46 enrolled

Overview

The SarcoV study aims at assessing the association between sarcopenia and the indication of mechanical ventilation in older hospitalized patients due to COVID-19 infection

Sarcopenia is disease associated with poor clinical outcomes. In critical ill chirurgical patients, sarcopenia is associated with difficult to wean of mechanical ventilation. The association between sarcopenia and mechanical ventilation is poorly studied in medical patients. COVID-19 pandemic has led a lot of medical patient to be admitted in intensive care units due to acute respiratory failure with need of mechanical ventilation support. The primary objective is to determine if sarcopenia in critically-ill older patients with COVID-19 is associated with the indication of mechanical ventilation. Secondarily, the study aims at determining if sarcopenia is associated with difficult to wean and mortality in critically-ill older patients with COVID-19.

Study Type

OBSERVATIONAL

Enrollment

Conditions

Sarcopenia

Eligibility

Sex: ALLMin age: 60 Years

Medical Language ↔ Plain English

Inclusion criteria * Consecutive patients aged 60 and older * Admission in an acute care unit in Brugmann university hospital due to a COVID-19 possible or confirmed infection. A infection was considered confirmed in presence of a positive molecular test by Polymerase-chain reaction (PCR), following the Belgian Public Health Department recommendations (Sciensano recommendations). Exclusion criteria * Patients unable to perform a grip-strength measurement due to any rheumatological or neurological condition.

Locations (1)

Brugmann university hospital

Brussels, Belgium

Outcomes

Primary Outcomes

Indication of mechanical ventilation

Association between probable sarcopenia and the indication of mechanical ventilation in patients with COVID-19 infection. Mechanical ventilation was considered by non-invasive ventilation or invasive ventilation. For purpose of analysis, it was defined as a binary outcome (yes(no). Probable sarcopenia probable was defined according to the revised European consensus on definition and diagnosis of sarcopenia (EWGSOP2). For purpose of analysis, it was defined as a binary condition (yes/no).

Time frame: Through study completion, an average of 60 days

Secondary Outcomes

Evaluate difficult-to-wean in mechanical ventilation

Difficult to wean in mechanical ventilation is defined if the patient required more than 7 days of mechanical ventilation from the first spontaneous breath test or if the patient was reintubated within 48 hours after extubation. For purpose of analysis, it was considered as a binary outcome (yes/no)

Time frame: Through study completion, an average of 60 days

All-cause mortality

Vital status during hospital admission, at 30- and 60-day follow-up

Time frame: Through study completion, an average of 60 days

Data from ClinicalTrials.gov

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