Spanish Study to Analyze the Histopathological, Ultrastructural and Microbiological Findings Obtained in Autopsies of Patients Who Died Due to COVID-19

Maimónides Biomedical Research Institute of Córdoba50 enrolled

Overview

The aim of this study is prospectively analyzing the histopathological, ultrastructural and microbiological findings from autopsies performed on patients with COVID-19.

The aim of this study is to increase the knowledge of the pathogenic mechanisms of the COVID-19 disease, that will allow us to improve the design of clinical and therapeutic strategies against the disease. This is the tool to improve the prognosis of patients with COVID-19. The performance of systematic and regulated autopsies can help to manage it. However, despite the need to generate this knowledge and the strong impact on mortality caused by the COVID-19 pandemic, the evidence from post-mortem studies is very limited.

Study Type

OBSERVATIONAL

Enrollment

Conditions

Covid19

Interventions

AutopsyOTHER

The subjects deceased will undergo an autopsy to analyze the histopathological, ultrastructural and microbiological findings, related to the COVID-19 disease.

Eligibility

Sex: ALL

Medical Language ↔ Plain English

Inclusion Criteria: * Patients with COVID-19 infection confirmed by PCR. * Death related to active infection by COVID-19 or its complications. * Informed consent given by the subject's relatives to perform an autopsy according to the autonomous community requirements. * Informed consent given by the subject's relatives for the inclusion of samples in the Biobank. Exclusion Criteria: * COVID-19 infection diagnosed exclusively by serological methods. * Advanced or terminal chronic disease. * Inadequate security level of the autopsy room.

Locations (10)

Marqués de Valdecilla University Hospital

Santander, Cantabria, Spain

RECRUITING

Puerta de Hierro University Hospital

Majadahonda, Madrid, Spain

RECRUITING

Outcomes

Primary Outcomes

Histopathological and ultra-structural findings

To analyze the histopathological and ultra-structural findings obtained in complete and systematic autopsies of patients who died due to COVID-19.

Time frame: End of autopsy

Secondary Outcomes

Molecular characterization

To analyze the presence and molecular characterization of COVID-19 in the different organs obtained in autopsies of patients deceased by COVID-19.

Time frame: End of autopsy

Hidden pulmonary superinfections

To evaluate the frequency of hidden pulmonary superinfections (bacterial and fungal disease) in patients who died due to COVID-19.

Time frame: End of autopsy

Histopathological / ultra-structural findings and clinical / biological expression correlation

To correlate the histopathological and ultra-structural findings obtained in autopsies with the clinical and biological expression of patients who died due to COVID-19.

Time frame: End of autopsy

Central Contacts

Antonio Rivero Román, MD

CONTACT

0034671596070 ariveror@gmail.com

María C Romero

CONTACT

0034671596070 mcarmen.romero@imibic.org

Data from ClinicalTrials.gov

This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.