Incidence, Risk Factors and Consequences of Acute Kidney Injury in Patients Undergoing Esophageal Cancer Surgery

Azienda Ospedaliera di Padova254 enrolled

Overview

Esophagectomy serves as an exemplar of major operative trauma, with well-known risk of pulmonary, cardiac, anastomotic, and septic complications and the presence of postoperative complications after esophagectomies for cancer is associated with a reduced long-term survival. There is a paucity in the literature regarding postoperative renal outcomes after esophageal surgery, with a wide range of incidence. The investigators will conduct a historical cohort study aiming to evaluate the incidence of postoperative acute kidney injury in patients undergoing elective esophageal cancer surgery. Secondary, the investigators will assess the progression of the acute injury and the association with adverse pulmonary, cardiac, anastomotic, and septic events, as well as increase in hospital stay and mortality. The investigators will also identify risk factors associated with acute kidney injury occurrence.

Study Type

OBSERVATIONAL

Enrollment

254

Conditions

Acute Kidney Injury Postoperative Complications

Eligibility

Sex: ALLMin age: 18 YearsMax age: 99 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Elective esophagectomy Exclusion Criteria: * End-stage renal disease * Missing data for acute kidney injury definition * Second surgery (for patients having multiple surgeries performed during a 30-day period, only the first in each period will be included)

Locations (1)

Outcomes

Primary Outcomes

Incidence of postoperative acute kidney injury

according to KDIGO criteria

Time frame: within 48 hours after surgery

Secondary Outcomes

Incidence of transient or persistent postoperative acute kidney injury

according KDIGO criteria

Time frame: 48 hours after development of acute kidney injury

Number of patients with renal recovery

according ADQI criteria

Time frame: at 7 days, after 30 days and 3 months

Incidence of postoperative pulmonary complications

based on European Perioperative Clinical Outcome (EPCO) definitions

Time frame: within 30 days after surgery

Incidence of major adverse cardiac and cerebrovascular events (MACCE)

composite outcome of non-fatal cardiac arrest, acute myocardial infarction, congestive heart failure, new cardiac arrhythmia, angina, ischemic stroke

Time frame: within 30 days after surgery

Incidence of sepsis

according Sepsis-3 definition

Time frame: within 30 days after surgery

Mortality in hospital

any death during the admission when the operation was performed

Time frame: 1 year

Increase in length of hospital stay

compared to the expected length of hospital stay according ACS NSQIP calculation

Time frame: 1 year