Safety Evaluation of LSCD101 Transplantation for Limbal Stem Cell Deficiency

Inclusion Criteria: * Men and women aged 19 or older * Diagnosed with intractable limbal stem cell deficiency in single eye, with severity in which corneal neovascularization invades more than two quadrants * No improvement of indication by known treatment (non-surgical/surgical) method according to investigator's judgment * BCVA 20/40 or less at screening in the eye with the limbal stem cell deficiency * Voluntarily agreed to participate in this study and signed a consent form Exclusion Criteria: * Inappropriate for harvesting limbal epithelial cells for the production of limbal epithelial cell sheet. * Difficulty in reconstruction of the corneal epithelium because the eye is not closed due to eyelid function problems in the eye with the limbal stem cell deficiency. * Severe dry eye with problem with tear secretion in both eyes (value of Schirmer I test without anesthesia \< 2 mm/5 min at screening) * Acute ocular surface inflammation of both corneas at Visit 2 * Malignant tumor history (except in case of no recurrence more than 5 years after surgery) * Uncontrolled comorbidities such as moderate to severe infections and bleeding * Positive for virus infection (HBV, HCV, HIV, CMV, HTLVⅠ/Ⅱ, syphilis) * Uncontrolled diabetes (HbA1c ≥9.0%) * Uncontrolled hypertension (SBP \> 140 mmHg or DBP \> 90 mmHg despite taking antihypertensives at screening) * Uncontrolled glaucoma (IOP \> 21 mmHg despite taking glaucoma medication) * Pregnant or lactating women * Women with childbearing potential, those who do not agree to contraception by medically accepted contraceptive methods during clinical trials * Participation in another clinical study within 4 weeks * Subjects judged by the investigator to be inappropriate to participate in the clinical study