Neutrophil Phenotypic Profiling and Surgical Site Infections in Surgical Patients

N/AActive Not RecruitingNCT04773457

Boston Children's Hospital220 enrolled

Overview

Surgical site infections (SSIs) are one of the major hospital acquired infections and responsible for the most cost among the hospital acquired infections. The objective of this study is to assess the neutrophil functional profiles and their associations with SSIs.

Study Type

OBSERVATIONAL

Enrollment

220

Conditions

Surgical Site Infection

Interventions

Surgical Site InfectionOTHER

infection at the site of the surgery (spine or abdomen)

Eligibility

Sex: ALLMin age: 12 MonthsMax age: 19 Years

Medical Language ↔ Plain English

Inclusion Criteria: * scheduled for an elective open gastrointestinal surgical procedure or spine fusion surgery Exclusion Criteria: * On chronic immunosuppressive drugs such as chronic corticosteroid use * preexisting immunodeficiency diseases

Locations (1)

Boston Children's Hopsital

Boston, Massachusetts, United States

Outcomes

Primary Outcomes

Neutrophil populations

compare neutrophil population between patients with SSI and without SSI by delineating transcriptomic profiles

Time frame: up to 3 days

Neutrophil functional impairment

illustrate neutrophil subpopulation associated with neutrophil functional impairment and SSIs by probing phagocytosis and reactive oxygen species formation

Time frame: up to 3 days

Data from ClinicalTrials.gov

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