This study aims to examine the link between Non-Alcoholic Fatty Liver Disease (NAFLD) and cardiovascular diseases by studying the association between liver fibrosis degree and cardiovascular risk factors. The study would clarify the value and the role of the Coronary calcium score (CAC score) in the screening for coronary disease in this population at high cardiovascular risk.
Hepatic Fibrosis and Cardiovascular Risk are evaluated by non invasive tests
Study Type
OBSERVATIONAL
Enrollment
292
Hôpital St Joseph
Marseille, France
Clinique Pasteur
Toulouse, France
Coronary calcium score
Score in Agatston IU of coronary atherosclerosis risk;ranging from 0 to 100 : low risk; 100 to 400 : intermediate risk and \> 400 : high risk of coronary atherosclerosis.
Time frame: At inclusion
Shear wave liver elastography
Hepatic elasticity assessed in kPa : \<5 Kpa : normal; 5 to 8 kPa : low to moderate fibrosis ; \> 8 kPa : advanced fibrosis; \>15 kPa : cirrhosis
Time frame: At inclusion
ARFI Hepatic elasticity
Hepatic elasticity assessed by Acoustic radiation force impulse (ARFI) (in kPa) Hepatic elasticity assessed in kPa : \<5 Kpa : normal; 5 to 8 kPa : low to moderate fibrosis ; \> 8 kPa : advanced fibrosis; \>15 kPa : cirrhosis .
Time frame: At inclusion
Cardiovascular risk
Systemic Coronary Risk Estimation (SCORE) ranging from \<1% very low risk to \>15% very high risk of cardiovascular mortality
Time frame: At inclusion
Coronary heart disease
Diagnosis of coronary heart disease
Time frame: 3 month
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