Intensive Control of Blood Pressure in Acute Ischemic Stroke After Endovascular Therapy on Clinical Outcome (CRISIS I)

Inclusion Criteria: * Age ≥18 years * Diagnosis of AIS with anterior circulation LVO confirmed by brain imaging * To receive MT \<24 hours after AIS onset according to local guidelines * Successful recanalization (TICI score ≥2b) after MT * Sustained systolic BP ≥140 mmHg (defined as 2 successive readings \<10 mins) within 60 minutes after recanalization * Provide written informed consent (or approved surrogate) * Perform CTA or MRI before endovascular therapy * Signed an approved informed consents Exclusion Criteria: * Significant pre-stroke disability (mRS scores 2-5) * Definite indication/contraindication to different intensities of BP lowering treatment * Specific contraindications to any of the BP agents to be used (eg, patients who are hypersensitive (allergic) to any of the ingredients) * Unlikely to potentially benefit from therapy (e.g. advanced dementia) or very high likelihood of death within 24 hours post-MT, judged by responsible treating clinician * Other medical illness that interferes with outcome assessments and follow-up (e.g.advance cancer and renal failure); Women who are lactating * Other conditions inappropriate for inclusion judged by investigators