Safety and Efficacy of USB002 for Respiratory Distress Due to COVID-19

Inclusion Criteria: 1. Signed informed consent from patient or legal representative; 2. Age 18 or greater; 3. Positive reverse transcription polymerase chain reaction (RT-PCR) for SARS-CoV-2 (≤10 days); 4. Respiratory rate \> 20 RR; 5. SpO2 \< 94% on room air, requiring supplemental oxygen, requiring invasive mechanical ventilation, or requiring ECMO; 6. Chest X-ray confirming bilateral pulmonary infiltrates; 7. Body mass index of ≤ 40 units/kg/m2; 8. Adequate method of birth control. Exclusion Criteria: 1. Terminally ill patients due to underlying cardiac, cancer or severe debilitating neurological disease including coma; 2. Hospitalization expected to be \< 96 hours due to medical improvement; 3. Interstitial lung disease; 4. Correction of QTc values obtained by 12 lead EKG using Fredericia's formula (QTcF) \> 450 ms; 5. History of hypotension (mean arterial blood pressure \< 65 mmHg), unrelated to CoVID-19 infection; 6. Alanine aminotransferase (ALT) or aspartate aminotransferase (AST) \> 3 times upper limit of normal; 7. Participating concurrently on another clinical trial for the experimental treatment of COVID-19; 8. Active chemotherapy use; 9. Pregnant and/or lactating women.