This study investigates the extent to which lifestyle factors including mental health, social support, diet, and exercise are associated with quality of life and melanoma patient outcomes. Knowledge gained from this study may be used to guide the design of prospective clinical trials of lifestyle interventions to improve the outcomes of melanoma patients and assist doctors in counseling their patients.
PRIMARY OBJECTIVES: I. Collect systematic data on mental health, quality of life (QOL), social support, diet, and exercise behaviors in melanoma patients. II. Examine whether psychosocial factors and lifestyle are associated with clinical outcomes in melanoma patients. III. Examine the association between lifestyle and psychosocial factors and tissue and blood biomarkers in melanoma patients. IV. Examine whether psychosocial factors and lifestyle are associated with QOL adjustment in melanoma patients. OUTLINE: Patients complete a maximum of 3 paper or electronic questionnaires over 30 minutes within 2 weeks of presentation to MD Anderson, new diagnosis of melanoma, and/or initiating a new treatment, within 2 weeks of first restaging, and within 2 weeks of the end of treatment. Patients may complete an additional paper or electronic dietary questionnaire over 10 minutes for 3 days (30 minutes total) or a phone-based dietary recall. Patients who start a new treatment of interest may repeat the questionnaires at the same time points. Patients' medical records are also reviewed.
Study Type
OBSERVATIONAL
Enrollment
5,000
Medical charts are reviewed
Complete questionnaires
M D Anderson Cancer Center
Houston, Texas, United States
RECRUITINGChange in depression/distress
Will be assessed using the Centers for Epidemiologic Studies - Depression. Lifetime history of Major Depressive Disorder (MDD) will be measured using the two cardinal items from the Structured Clinical Interview for Diagnostic and Statistical Manual of Mental Disorders-IV Disorder. Multivariate methods, including repeated measures analyses, will be employed to further explore the potential changes in the measures over time.
Time frame: Up to 10 years
Change in anxiety
Will be assessed using the Speilberger State/Trait Anxiety Inventory. Multivariate methods, including repeated measures analyses, will be employed to further explore the potential changes in the measures over time.
Time frame: Up to 10 years
Change in cancer-related symptoms
Will be assessed using the MD Anderson Symptom Inventory. Multivariate methods, including repeated measures analyses, will be employed to further explore the potential changes in the measures over time.
Time frame: Up to 10 years
Change in social support
Will be assessed using the 24-item Social Provisions Scale. Multivariate methods, including repeated measures analyses, will be employed to further explore the potential changes in the measures over time.
Time frame: Up to 10 years
Change in general eating habits
Will be assessed using the National Cancer Institute National Health and Nutrition Examination Survey Dietary Screener Questionnaire, and optionally, the National Institutes of Health Automated Self-Administered 24-hour.
Time frame: Up to 10 years
Change in physical activity
Will be assessed using the Godin Leisure -Time Exercise Questionnaire. Multivariate methods, including repeated measures analyses, will be employed to further explore the potential changes in the measures over time.
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Time frame: Up to 10 years
Associations between mental health, social support, diet and exercise behaviors, and quality of life and demographic variables
Will be evaluated using Pearson's product moment correlation coefficients together with scatterplots where appropriate.
Time frame: Up to 10 years
Effect of diet, physical activity, depressive symptoms, distress, lifetime MDD, and social support on progression free survival
Will be evaluated using Pearson's product moment correlation coefficients together with scatterplots where appropriate.
Time frame: Up to 10 years
Effect of diet, physical activity, depressive symptoms, distress, lifetime MDD, and social support on cancer mortality
Will be evaluated using Pearson's product moment correlation coefficients together with scatterplots where appropriate.
Time frame: Up to 10 years
Response to treatment
Logistic regression models will be used to measure the association of diet, physical activity, diet, depressive symptoms, distress, lifetime MDD, and social support and response to treatment at each time point.
Time frame: Up to 10 years