Patients with established cardiovascular disease (CVD) often have multiple medications that increase the risk of prevalence of drug therapy problems (DTP), subsequently leading to unfavourable clinical and health outcomes. By providing Comprehensive Medication Management (CMM) services to patients within a healthcare system, pharmacists assess patients' medication-related needs, identify and prevent DTP, develop individualized care plan for each individual patient and evaluate and monitor outcomes. Thus, the CMM services delivered at the primary care level in collaboration with general practitioners and other healthcare providers could address this problem and by optimizing therapy improve patients' clinical outcomes and quality of life. Studies have shown that patients with chronic diseases have the greatest benefit from the CMM services. The aim of this study is to evaluate the impact of CMM services on clinical and humanistic outcomes in patients with established CVD. The study will employ prospective, longitudinal, pre- and postintervention study with a 1-year patient follow-up.
Study Type
INTERVENTIONAL
Allocation
NON_RANDOMIZED
Purpose
HEALTH_SERVICES_RESEARCH
Masking
NONE
Enrollment
133
Comprehensive Medication Management services (CMM services) is an evidence-based and patient-centred service which involves an assessment of patient's medications to determine that each medication is appropriate, effective for the medical condition being treated, safe for the patient in the presence of other medications and co-morbidities, and that the patient is able and willing to take the medications as intended. As all patient care providers need a structured, rational thought process for sound clinical decision retrieval, the Pharmacotherapy Workup was developed and adopted as a systematic problem-solving process. This process represents the cognitive work taking place in the mind of the practitioner, and is used to identify, resolve, and prevent drug therapy problems (DTP), establish therapy goals, select interventions and evaluate outcomes.
Health Care Centre Zagreb - Centre
Zagreb, Croatia
University of Zagreb Faculty of Pharmacy and Biochemistry
Zagreb, Croatia
The impact of CMM services on blood pressure in elderly patients with established CVD
Within- and between-treatment differences for the intervention and the control group in blood pressure.
Time frame: 1 year
The impact of CMM services on LDL cholesterol, triglycerides, HDL cholesterol and total cholesterol in elderly patients with established CVD
Within- and between-treatment differences for the intervention and the control group in LDL cholesterol (mmol/L), triglycerides (mmol/L), HDL cholesterol (mmol/L) and total cholesterol (mmol/L).
Time frame: 1 year
The impact of CMM services on health care utilization in elderly patients with established CVD
Between-treatment difference in the number of hospital admissions, emergency department visits and unplanned GPs visits.
Time frame: 1 year
The impact of CMM services on drug therapy problems in elderly patients with established CVD
Number and type of drug therapy problems in the intervention group.
Time frame: 1 year
The impact of CMM services on health related quality of life in elderly patients with established CVD assessed by EQ-5D-5L instrument.
Change from baseline in health related quality of life assessed by EQ-5D-5L instrument in the intervention group.
Time frame: 1 year
The impact of CMM services on glycated haemoglobin in elderly patients with established CVD
Within- and between-treatment differences for the intervention and the control group in glycated haemoglobin.
Time frame: 1 year
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