The purpose of this study is to assess the effect of Lactobacillus rhamnosus CNCM I-3690 consumption on subjective anxiety levels in healthy subjects undergoing academic stress.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
SUPPORTIVE_CARE
Masking
QUADRUPLE
Enrollment
168
2 bottles of 100g consumed daily during 28 days
UZ/KU Leuven
Leuven, Belgium
Comparison between groups of the State-Trait Anxiety Inventory (STAI)-state questionnaire score during 4 weeks of investigational product consumption.
Time frame: At Baseline and after stress challenge (4 weeks after baseline).
Comparison between groups of cortisol level in saliva, Perceived Stress Scale (PSS) questionnaire score and Heart Rate Variability (HRV) during 4 weeks of investigational product consumption.
Time frame: At Baseline and after stress challenge (4 weeks from baseline).
Comparison between groups of sleep efficiency, total sleep time, and deep sleep (Non-REM 3 sleep cycle) duration, during 4 weeks of investigational product consumption.
Time frame: At Baseline and at stress challenge (4 weeks from baseline).
Comparison between groups of Bond-Lader visual analogue scale (VAS) score during 4 weeks of investigational product consumption.
Time frame: At Baseline and at stress challenge (4 weeks from baseline).
Comparison between groups of cortisol levels in saliva after 4 weeks of investigational product consumption.
Time frame: Time course of cortisol secretion on the day of the stress challenge (5 timepoints).
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