Psychosocial and lifestyle factors in Army recruits likely contribute to increased susceptibility to infection and injury during basic Army training. The primary aim of this study is to assess the influence of psychosocial and lifestyle factors at the start of basic Army training on immune health (e.g. respiratory infection and antibody response to influenza vaccination) and injury during training, in an observational design. A secondary aim is to establish whether changes in psychosocial and lifestyle factors during training impact immune health (e.g. response to hepatitis B vaccination). Using an interventional design, participants will be randomly allocated into two experimental groups: (i) Routine vaccination group: to receive first hepatitis B vaccination at initial medical assessment upon entry to basic training and second hepatitis B vaccination 1 month later; (ii) Delayed vaccination group: to receive first hepatitis B vaccination during week 5 of training and second hepatitis B vaccination 1 month later.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
BASIC_SCIENCE
Masking
NONE
Enrollment
1,188
First and second hepatitis B vaccinations will be delayed by 1 month in the interventional group to establish whether changes in psychosocial and lifestyle factors during training impact immune health.
Infantry Training Centre
Catterick, North Yorkshire, United Kingdom
Antibody response to influenza vaccination - Aim 1
Time frame: 1 month
Physician diagnosed respiratory infection incidence - Aim 1
Time frame: 6 months
Physician diagnosed injury incidence - Aim 1
Time frame: 6 months
Antibody response to second hepatitis B vaccination - Aim 2
Time frame: Routine group: 3 months; Delay group: 4 months
Antibody response to influenza vaccination
Time frame: 4 months
Antibody response to first hepatitis B vaccination
Time frame: Routine group: 1 months; Delay group: 2 months
C-reactive protein
Time frame: Baseline, 1-day post vaccination and 1 month
Gene expression profiling
Time frame: Baseline and 1 month
Epstein Barr Virus serostatus/antibody titre
Time frame: Baseline and 1 month
Cytomegalovirus serostatus/antibody titre
Time frame: Baseline and 1 month
Torque Teno Virus plasma DNA
Time frame: Baseline and 1 month
Interleukin-6
Time frame: Baseline and 1 month
Hair cortisol
Time frame: Baseline
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