The purpose of this study is to investigate if treatment of periodontitis (gum disease) in a relatively young and healthy population can improve lung function. It is hypothesized that removing the dental biofilm reduce the source of inflammatory bacteria that can reach the lungs, and thereby reduce lung inflammation and lead to improved lung function.
After being informed about the study and potential risks, all participants giving written informed consent will undergo a clinical screening to determine eligibility for study entry. The study participants will be randomized into two groups. Half of the study participants will after baseline move directly into an active periodontal treatment phase including oral hygiene instructions and professional tooth cleaning by a full mouth disinfection protocol (intervention 2). New data will be collected after 6-8 weeks of healing. The second study group will after baseline receive prophylactic periodontal treatment by oral hygiene instructions and supragingival plaque removal (intervention 1). New data will be collected after 3-4 weeks. This group will now receive the active periodontal treatment phase (intervention 2) like the first study had initially. New data will be collected after 6-8 weeks of healing. Both groups will receive supportive periodontal treatment every 3 months in 12 months after intervention 2.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
PREVENTION
Masking
DOUBLE
Enrollment
62
Periodontal treatment (scaling and rootplaning) with adjunctive chlorhexidine use
Department of Clinical Dentistry, University of Bergen
Bergen, BERGEN, Norway
Forced Vital Capacity (FVC) (L)
Change in Forced vital capacity in liters (L).
Time frame: Baseline, 3 weeks, 6 weeks, 3 months, 6 months, 9 months and 12 months
Forced Expiratory Volume in one second (FEV1) (L)
Change in Forced expiratory volume in one second in liters (L).
Time frame: Baseline, 3 weeks, 6 weeks, 3 months, 6 months, 9 months and 12 months
Forced Oscillation Technique (FOT)
Change in lung function measured by Forced Oscillation Technique (FOT). Outcome parameters are: Resistance at 5Hz (R5) \[kPaL-1s\] Resistance at 20Hz (R20) \[kPaL-1s\] Reactance at 5 Hz (X5) \[kPaL-1s\] Reactance area AX \[kPaL-1\] and Resonance frequency (fres) \[Hz\].
Time frame: Baseline, 3 weeks, 6 weeks, 3 months, 6 months, 9 months and 12 months
Sampling of plaque bacteria
Saliva and plaque collected at inclusion and from each follow-up will be analyzed with high-throughput sequencing techniques to characterize the bacteria that are present. Bacterial DNA will be isolated from the samples and the 16S rRNA bacterial gene will be amplified and sequenced by Illumina® MiSeq platforms. Shotgun sequencing will also be applied on a subsample to allow full resolution and identification of bacteria at species and subspecies taxonomic level.
Time frame: Change from baseline at 6 months
Fractional exhaled nitric oxide (FeNO)
Change in FeNO at exhalation flow-rate of 50 mL/s, measured in parts per billion (ppb).
Time frame: Baseline, 3 weeks, 6 weeks, 3 months, 6 months, 9 months and 12 months
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