Cardiovascular disease is the main cause of death worldwide. Endothelial dysfunction is the first step to development of cardiovascular diseases. Endothelial dysfunction occurs due to reduction in nitric oxide, a molecule that plays an important role on vascular health. Due to important role of nitric oxide in endothelial function, several studies have evaluated the effect of its precursors, such as L-citrulline and nitrate on endothelial function parameters. The present study will evaluate the effect of L-citrulline and nitrate derived by watermelon and beetroot products, respectively, on endothelial function of young and older participants. Furthermore, we will evaluate the plasmatic amino acids, nitrate, glucose and insulin in response to ingestion of these products.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
PREVENTION
Masking
DOUBLE
Enrollment
12
A single dose of watermelon powder containing 3g of L-citrulline
A single dose of beetroot powder containing 8 mmol of nitrate
A single dose of watermelon and beetroot powder containing 3g of L-citrulline and 8 mmol of nitrate
A single dose of maltodextrin
Universidade Federal do Rio de Janeiro
Macaé, Rio de Janeiro, Brazil
Flow-mediated dilation (FMD)
Time frame: This measure will be evaluate before the nutritional intervention
Flow-mediated dilation (FMD)
Time frame: This measure will be evaluate 60 minutes after the nutritional intervention
Flow-mediated dilation (FMD)
Time frame: This measure will be evaluate 120 minutes after the nutritional intervention
Muscle oxygen saturation
Time frame: This measure will be evaluate before the nutritional intervention
Muscle oxygen saturation
Time frame: This measure will be evaluate 30 minutes after the nutritional intervention
Muscle oxygen saturation
Time frame: This measure will be evaluate 60 minutes after the nutritional intervention
Muscle oxygen saturation
Time frame: This measure will be evaluate 90 minutes after the nutritional intervention
Muscle oxygen saturation
Time frame: This measure will be evaluate 120 minutes after the nutritional intervention
Plasmatic amino acids
Time frame: This measure will be evaluate before the nutritional intervention
Plasmatic amino acids
Time frame: This measure will be evaluate 30 minutes after the nutritional intervention
Plasmatic amino acids
Time frame: This measure will be evaluate 60 minutes after the nutritional intervention
Plasmatic amino acids
Time frame: This measure will be evaluate 90 minutes after the nutritional intervention
Plasmatic amino acids
Time frame: This measure will be evaluate 120 minutes after the nutritional intervention
Plasmatic glucose
Time frame: This measure will be evaluate before the nutritional intervention
Plasmatic glucose
Time frame: This measure will be evaluate 30 min after the nutritional intervention
Plasmatic glucose
Time frame: This measure will be evaluate 60 min after the nutritional intervention
Plasmatic glucose
Time frame: This measure will be evaluate 90 min after the nutritional intervention
Plasmatic glucose
Time frame: This measure will be evaluate 120 min after the nutritional intervention
Plasmatic insulin
Time frame: This measure will be evaluate before the nutritional intervention
Plasmatic insulin
Time frame: This measure will be evaluate 30 min after the nutritional intervention
Plasmatic insulin
Time frame: This measure will be evaluate 60 min after the nutritional intervention
Plasmatic insulin
Time frame: This measure will be evaluate 90 min after the nutritional intervention
Plasmatic insulin
Time frame: This measure will be evaluate 120 min after the nutritional intervention
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