This study investigates the effects of preoperative use of oral combination of duloxetine and Pregabalin in comparison with preoperative oral Pregabalin only in treatment of acute postoperative and prevention of chronic pain following thoracotomy surgeries.
75 Patients, undergoing thoracotomy surgery will be randomly allocated into three equal groups, each (n=25 ), using computerized generated random tables: Group P: will receive oral Pregabalin 75mg two hour preoperatively, 12 hours postoperative and will continue for one week twice per day. Group D:will receive oral duloxetine 30mg two hour preoperatively …will be continued for one week once per day after breakfast . Group C: will receive single dose of Pregabalin 75mg + duloxetine 30mg two hour preoperatively, 75mg pregabalin 12 hour postoperative and then will continue pregabalin twice per day +duloxetine once after breakfast for one week. The total amount of morphine consumption in the first 24 hours postoperatively, total amount of intraoperative fentanyl will be recorded, change in hemodynamics ((heart rate and mean arterial blood pressure), respiratory rate and oxygen saturation will be monitored and recorded at 0,2, 4, 8, 12 ,16 \&24 hours and Visual analogue scale at 0, 2,4, 8, 12, 16 \&24 hours postoperatively then at 3rd, 5th days, 4th week and12th week will be measured.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
QUADRUPLE
Enrollment
75
Pregabalin 75mg two hour preoperatively, 12 hours postoperative and will continue for one week twice per day.
Duloxetine 30mg two hour preoperatively …will be continued for one week once per day after breakfast .
Bassant abdelhamid
Cairo, Egypt
RECRUITINGVisual analogue scale
Using a ruler, the score is determined by measuring the distance (mm) on the 10-cm line between the "no pain" anchor and the patient's mark, providing a range of scores from 0-100. A higher score indicates greater pain intensity.
Time frame: 24 hours postoperative
Visual analogue scale
Using a ruler, the score is determined by measuring the distance (mm) on the 10-cm line between the "no pain" anchor and the patient's mark, providing a range of scores from 0-100. A higher score indicates greater pain intensity.
Time frame: 12 weeks
Total dose of intraoperative fentanyl.
The total dose of intraoperative fentanyle administration rather than the dose used in induction
Time frame: 2 hours intraoperative
Heart rate
Heart rate will be measured preoperative as baseline value, intraoperative and postoperative
Time frame: 24 hours
Mean arterial pressure
Mean arterial blood pressure will be measured preoperative as baseline value, intraoperative and postoperative.
Time frame: 24 hours postoperative
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