Study on the Application of Saliva EBV-DNA Detection in EBV Infection Related Diseases

Beijing Friendship Hospital40 enrolled

Overview

This study is a single-center, prospective, observational clinical study to evaluate the Application of saliva EBV-DNA Detection in EBV Infection Related Diseases

Study Type

OBSERVATIONAL

Enrollment

Conditions

EBV Infection

Interventions

Saliva TestingDIAGNOSTIC_TEST

Saliva EBV-DNA Detection comparing with PBMC and plasma EBV-DNA

Eligibility

Sex: ALLMin age: 3 YearsMax age: 65 Years

Medical Language ↔ Plain English

Inclusion Criteria: 1. According to the HLH-04 diagnostic criteria, it meets the HLH diagnostic criteria. EBV infection occurs in cells with EBV-DNA copy number significantly increased in peripheral blood or tissue, or where EBV coding small RNA(EBER) is detected in tissue or peripheral blood. Or Straus' 1988 diagnostic criteria for CAEBV. 2. Informed consent Exclusion Criteria: 1. Patients who cannot cooperate with saliva collection 2. Patients who are unwilling to cooperate with the project research according to the project research plan.

Locations (1)

Beijing Friendship Hospital, Capital Medical University

Beijing, Beijing Municipality, China

RECRUITING

Outcomes

Primary Outcomes

Diagnosis

The sensitivity and specificity of saliva EBV-DNA detection level as a diagnosis for EBV infection-related diseases, and whether it can replace peripheral blood EBV-DNA monitoring

Time frame: baseline

Monitoring

The sensitivity and specificity of saliva EBV-DNA detection level as a monitoring method for EBV infection-related diseases, and whether it can replace peripheral blood EBV-DNA monitoring

Time frame: 2 to 12 weeks after treatment

Central Contacts

Zhao Wang, Dr

CONTACT

+8618810253070 wangzhao@ccmue.du.cn

Data from ClinicalTrials.gov

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