This project aims to conduct a pilot study based on the targeting of the epileptogenic zone previously localized very precisely by stereoelectroencephalography (SEEG). SEEG is used as part of the pre-surgical assessment. It consists, thanks to the intracerebral implantation of electrodes in the brain of patients, to perform an intracerebral electrophysiological recording and thus to precisely explore the epileptogenic regions. In order to study the neuromodulatory and therapeutic effects of tDCS on epileptic brains, non-invasive techniques for measuring electrophysiological brain activity such as magnetoencephalography (MEG) and high-resolution electroencephalography (HR EEG) will be used. Finally, since epilepsy is considered to be a disorder of brain functional networks associated with disturbed brain connectivity, the effects of tDCS on cortical excitability by studying the variations in functional connectivity induced by stimulation will be studied.
Study Type
INTERVENTIONAL
Allocation
NA
Purpose
TREATMENT
Masking
NONE
Enrollment
17
Patients will be treated using Starstim 8 device, a device allowing to perform transcranial direct current stimulation. The position of electrodes will be personalized based on the localization of the epileptogenic zone.
Service d'Epileptologie et de Rythmologie Cérébrale
Marseille, France
Seizure frequency
Percentage of change of seizures frequency
Time frame: Comparison between baseline and month 2
Seizure frequency
Percentage of change of seizures frequency
Time frame: Comparison between baseline and month 4
Seizure frequency
Percentage of change of seizures frequency
Time frame: Comparison between baseline and month 6
Seizure frequency
Percentage of change of seizures frequency
Time frame: Comparison between baseline and month 8
Depression
Neurological Disorders Depression Inventory for Epilepsy (NDDI-E) - score to 6 to 24, higher values mean worse outcome
Time frame: Comparison between baseline and month 8
Anxiety disorders
Generalized Anxiety Disorder-7 (GAD-7) - score between 0 to 21, higher values mean worse outcome
Time frame: Comparison between baseline and month 8
Seizures evaluation
National Hospital Seizure Severity Scale (NHS3) - score 1 to 31, higher values mean worse outcome
Time frame: Comparison between baseline and month 8
Brain functional connectivity
National Hospital Seizure Severity Scale (NHS3) score 1 to 31, higher values mean worse outcome
Time frame: Comparison between day 1 and day 5 of each session
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