Effect of Inspiratory Muscle Training on Physiological Function and Clinical Outcomes After Lung Transplant

Mayo Clinic30 enrolled

Overview

The purpose of this research is to study the effect of training the inspiratory muscles (i.e. the muscle that allow you to breath-in) on exercise capacity, quality of life, and short-term clinical outcomes in patients post lung transplant.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

SUPPORTIVE_CARE

Masking

DOUBLE

Enrollment

Conditions

Post-Lung Transplantation Bronchiectasis

Interventions

POWERBreathe Plus®DEVICE

Commercially available pressure-threshold device

Cardiopulmonary rehabilitation post lung transplantOTHER

Pulmonary function, lung diffusing capacity for carbon monoxide, inspiratory muscle strength, and diaphragm dimensions will be assessed in each patient. Each patient will also undergo a cardiopulmonary exercise test (CPET), 6 minute walk test, and an inspiratory muscle endurance test

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: \- All patients who undergo single- or double-lung transplant at Mayo Clinic Florida. Exclusion Criteria: * Patients who do not survive the intra-operative period during the transplant surgery. * Patients undergoing retransplantation. * Patients undergoing multiorgan transplantation. * Patients who are not willing to or who are unable to give written informed consent.

Locations (1)

Mayo Clinic in Florida

Jacksonville, Florida, United States

RECRUITING

Outcomes

Primary Outcomes

Maximal inspiratory mouth pressure (MIP) measured in cmH2O

The maximal strength generating capacity of the inspiratory muscles.

Time frame: 12 weeks

Secondary Outcomes

Maximal oxygen uptake (V̇O2max) measured in mL/kg/min

Vo2 max is the maximal measured oxygen uptake during a symptom limited exercise test.

Time frame: 12 weeks

Central Contacts

Bryan Taylor

CONTACT

taylor.bryan@mayo.edu

Data from ClinicalTrials.gov

This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.