Coronary CT Angio Evaluating Graft Patency in ACS Patients Treated With DAPT or Single ASA After CABG (CoCAP)

University Hospital, Linkoeping360 enrolled

Overview

The purpose of this study is to compare the presence of graft patency in single aspirin vs dual anti platelet therapy (DAPT) treatment including ticagrelor in patients with acute coronary syndrome (ACS) treated with coronary artery bypass surgery (CABG). Follow up time is 12-36 months postoperatively and the patency will be evaluated with coronary computed tomography angiography (CCTA)

Study Type

OBSERVATIONAL

Enrollment

360

Conditions

Acute Coronary Syndrome Coronary Bypass Stenosis

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Previously included in TACSI-trial Exclusion Criteria: * Highly irregular heart rhythm (i.e. atrial fibrillation) * Chronic kidney disease with estimated glomerular filtration rate (eGFR) \<45ml/min/1,73m2 * Body weight \>120 kg * Previous severe allergic reaction (i.e. anaphylactic reaction) to iodine-based contrast agents * Not able to communicate * Not willing to participate

Locations (6)

Department of Heart Disease, Haukeland University Hospital

Bergen, Norway

ENROLLING_BY_INVITATION

St Olavs University Hospital

Trondheim, Norway

NOT_YET_RECRUITING

Department of Molecular and Clinical Medicine, Wallenberg Laboratory, Institute of Medicine

Gothenburg, Sweden

ENROLLING_BY_INVITATION

Dep of Vascular and Thoracic Surgery

Örebro, Sweden

ACTIVE_NOT_RECRUITING

Department of Cardiothoracic Surgery Karolinska University Hospital

Stockholm, Sweden

ENROLLING_BY_INVITATION

University Hospital Linköping

Linköping, Östergötland County, Sweden

RECRUITING

Outcomes

Primary Outcomes

Graft patency after CABG

Defined as patency on CCTA (FitzGibbon A) without previous graft failure identified on CCTA and/or invasive coronary angio (ICA) since CABG, intention to treat (ITT) analysis.

Time frame: 12-36 months

Secondary Outcomes

Graft patency after CABG - PP analysis

Defined as patency on CCTA (FitzGibbon A) without previous graft failure identified on CCTA and/or ICA since CABG, per protocol (PP) analysis.

Time frame: 12-36 months

Graft patency after CABG

Defined as non-occlusion on CCTA (FitzGibbon A+B) without previous graft occlusion identified on CCTA and/or ICA since CABG, ITT analysis.

Time frame: 12-36 months

Graft patency after CABG

Defined as non-occlusion on CCTA (FitzGibbon A+B) without previous graft occlusion identified on CCTA and/or ICA since CABG, PP analysis.

Time frame: 12-36 months

Graft patency after CABG

Defined as patency on CCTA (FitzGibbon A) without graft failure identified on CCTA and/or ICA since CABG, patients on oral anticoagulants excluded, ITT (sensitivity analysis).

Time frame: 12-36 months

Graft patency after CABG

Defined as non-occlusion on CCTA (FitzGibbon A) without previous graft failure identified on CCTA and/or ICA since CABG, patients on oral anticoagulants excluded, PP (sensitivity analysis).

Time frame: 12-36 months

Coronary CT Angio Evaluating Graft Patency in ACS Patients Treated With DAPT or Single ASA After CABG (CoCAP)

Overview

Conditions

Eligibility

Locations (6)

Outcomes

Primary Outcomes

Secondary Outcomes

Central Contacts