PHASE 1 SARS-COV-2-Spike-Ferritin-Nanoparticle (SpFN) Vaccine With ALFQ Adjuvant for Prevention of COVID-19

Inclusion Criteria: * Must be a male or non-pregnant, non-breastfeeding female between the ages of 18 and 55 years, inclusive, at the time of enrollment. * Must be willing and able to read, sign, and date the informed consent document. * Must demonstrate an understanding of the study with a passing score (90% or greater) on the Test of Understanding (TOU) by the third attempt, before study-related procedures are performed. * Must be willing and able to comply with study requirements and be available for follow-up visits for the entire study. * Must have the means to be contacted by telephone and/or video for remote follow-up visits as needed. * Must have a body mass index (BMI) ≥18.1 kg/m2 and \<35.0 kg/m2. * Have no previously documented COVID-19/SARS-CoV-2 infection * Must agree to refrain from donating blood or plasma outside of this study for the duration of participation in this study. * Must have acceptable screening laboratory findings: white blood cell (WBC), hemoglobin, platelet count, prothrombin (PT), prothrombin time (PTT), aspartate transaminase (AST), alanine transaminase (ALT), alkaline phosphatase (ALP), creatinine, and total bilirubin) within 14 days before Study Day 1. * Must be healthy based on the physician investigator's clinical judgment after review of past medical history, medication use, vital signs, and an abbreviated physical examination. * Biological females must have a negative urine pregnancy test at screening and a negative urine pregnancy test immediately before each study injection. * Biological females of reproductive capacity must use an acceptable method of contraception, beginning 30 days before enrollment, and until at least 60 days after the last study injection. Exclusion Criteria: * Has plans to become pregnant or is currently pregnant or breastfeeding. * Seropositive to COVID-19 by binding antibody titer assay. * Confirmed positive for active infection of human immunodeficiency virus (HIV), hepatitis C virus (HCV), or presence of Hepatitis B surface antigen (HbsAg). * Has known or suspected congenital or acquired immunodeficiency, or recent history or current use of immunosuppressive therapy. * History of organ and or stem cell transplantation. * Has a history of malignancy other than squamous cell or basal cell skin cancer, unless there has been surgical excision that is considered to have achieved a cure. * Has diabetes mellitus type 1 or type 2 (including cases controlled with diet alone) and/or thyroid disease. * Has major psychiatric illness during the last 12 months that, in the physician investigator's opinion, would preclude participation. * Has a history of other chronic diseases or conditions * Has a current or history of substance abuse that, in the physician investigator's opinion, would preclude participation. * Has tattoos, scars, or other marks that would, in the opinion of the physician investigator, interfere with the assessment of the injection site. * Has a known allergy or history of anaphylaxis or other serious reaction to a vaccine, vaccine component, or latex. * Had major surgery (per the physician investigator's judgment) in the month before screening or has plans to have major surgery during the study. * Received blood products or immunoglobulin in the three months before screening or has plans to use during the study. * Donated a unit of blood within eight weeks before Study Day 1 or has plans to donate blood during the study. * Received an experimental COVID-19 vaccine outside of this study or a COVID-19 vaccine that has been given Emergency Use Authorization from the FDA * Received live attenuated vaccine from 30 days before Study Day 1 until 30 days after the last study injection. * Received killed or inactivated vaccine from 14 days before Study Day 1 and until 30 days after the last study injection. * Received experimental therapeutic agents within three months before the first study injection or has plans to receive any experimental therapeutic agents during the entire course of the study. * Concurrent participation in another study requiring blood draws or exposure to investigational or non-investigational vaccine/product (pharmaceutical or device) throughout the study period. * Has an acute illness or temperature ≥38.0 degrees Celsius (C)/100.4 degrees Fahrenheit (F) on any study injection day or within 48 hours of planned study injection. * In the physician investigator's opinion, is unable to communicate reliably, is unlikely to adhere to study requirements, or has a condition that would limit completion of the study. * Is unwilling to have their samples collected and stored for future research. * Emergency medical services personnel and healthcare provider with patient contact in potentially high risk/high exposure settings as per screening physician's assessment. * Current smoker or inhales vaporized nicotine "Vaping" daily. Current smoker is defined as an adult who has smoked 100 cigarettes in his or her lifetime and who currently smokes cigarettes.