4D Medical X-ray Velocimetry for Bronchoscopic Lung Volume Reduction Targeting

Vanderbilt University Medical Center17 enrolled

Overview

This study will investigate the utility of 4D Medical's X-ray Velocimetry (XV) imaging analysis software for the detection of hyperinflation, and compare endobronchial valve placement outcomes with predictive indices obtained utilizing this technique.

Study Type

OBSERVATIONAL

Enrollment

Conditions

Copd Emphysema Hyperinflation

Interventions

4D X-ray VelocimetryDIAGNOSTIC_TEST

X-ray velocimetry uses fluoroscopy to quantify local ventilation in the lung.

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion: * CT chest and PFTs within the last two years * Age over 18 * COPD with emphysema * Global Initiative for Chronic Obstructive Lung Disease (GOLD) 3 - 4 classification OR modified Medical Research Council (mMRC) score of 2 or greater. Exclusion Criteria: * Pregnancy * Presence of an additional pulmonary disease beyond COPD * Inability to raise arms above 90 degrees as required for fluoroscopy

Locations (1)

Vanderbilt University Medical Center

Nashville, Tennessee, United States

Outcomes

Primary Outcomes

Ratio of residual volume over functional residual capacity by 4DXV

We will compare an XV hyperinflation index to traditional pulmonary function tests (PFTs) and outcomes

Time frame: 6 months

Expiratory Time Constants vs Fissure Completeness

We will examine the correlation between lobar expiratory time constants and fissure completeness by StratX

Time frame: 1 year

Secondary Outcomes

Improvement in Saint George Respiratory Questionnaire (SGRQ)

We will compare SGRQs pre and post valve placement to hyperinflative indices by 4D XV

Time frame: 1 year

Data from ClinicalTrials.gov

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