Natural History and Patient Journey in Atrial Fibrillation: a Nationwide Linked Electronic Health Records Study of 5.6 Million Individuals.

University College, London5,601,803 enrolled

Overview

The trajectory of atrial fibrillation (AF) patients within the national health system and their recent temporal trends remains to be fully elucidated. To study the AF incidence, mortality and case-fatality, the investigators implemented a longitudinal cohort study with the linked electronic health records of 5.6 million population in the UK from 1998 to 2016 (CALIBER). A matched case-control study design was used to investigate the causes of hospitalization and death comparing individuals with and without incident AF.

Study Type

OBSERVATIONAL

Enrollment

5,601,803

Conditions

Atrial Fibrillation Epidemiology

Interventions

The study does not have an intervention, but observe the AF incidence of the UK disease-free populationOTHER

The study does not have an intervention, but observe the AF incidence of the UK disease-free population.

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * The investigators identify individuals aged 18 years or older and registered in the current primary care practice for at least one year. Exclusion Criteria: * Individuals are excluded if they had a prior history of AF before study entry.

Outcomes

Primary Outcomes

Incidence of Atrial fibrillation

AF incidence in the population

Time frame: Jan 1st 1998 - May 31st 2016

Mortality of Atrial fibrillation

Mortality among AF patients

Time frame: Jan 1st 1998 - May 31st 2016