Food or Supplemental Lutein Absorption

The University of Queensland

Overview

The aim of this study is to investigate in healthy adults, 18-40 years of age, how the absorption of 5 mg of L differs between consumption as a supplement, blended foods, and whole food equivalent of blended foods.

The absorption the macular carotenoids has shown variability between different supplements, and food sources such as egg and spinach. Investigation of the absorption of different forms of food (e.g. cooked, raw, blended) is not as well studied. Investigating the absorption of lutein from different forms of food is important to be able to prescribe lutein from forms of food that will be optimally absorbed.

Study Type

INTERVENTIONAL

Allocation

NON_RANDOMIZED

Purpose

BASIC_SCIENCE

Masking

NONE

Conditions

Macula Lutea Opacity

Interventions

Lutein supplementDIETARY_SUPPLEMENT

5 mg lutein supplement.

Food, blendedOTHER

5 mg lutein from baby spinach, blended.

Food, unprocessedOTHER

5 mg lutein from baby spinach, in whole food form.

Eligibility

Sex: ALLMin age: 18 YearsMax age: 40 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Male and females 18 to 40 years. * Generally healthy. * No participant reported history of clinically significant medical conditions including, but not limited to, cardiovascular, neurological, psychiatric, renal, immunological, endocrine (including uncontrolled diabetes or thyroid disease) or haematological abnormalities that are uncontrolled. * Non-smoker. * English language proficiency Exclusion Criteria: * Participant reported diagnosis of serious ocular conditions (e.g. cataracts, glaucoma, diabetic retinopathy, retinitis pigmentosa, Stagardt's disease) * Participant reported diagnosis, or current treatment of age-related macular degeneration. * Participant reported diagnosis of epilepsy. * Participant aversion, intolerance or allergy to study foods to be consumed (spinach, ginger, lemon, apple, flaxseeds) * A female currently pregnant or trying to fall pregnant. * Current or past smoker (within last 12 months). * Under 18 or over 40 years of age. * Currently taking a lutein supplement or consuming large amounts of foods containing lutein on a regular basis (\>3 days per week).

Locations (1)

School of Human Movement and Nutrition Sciences, The University of Queensland

Saint Lucia, Queensland, Australia

Outcomes

Primary Outcomes

Plasma lutein concentration

Area under the curve of plasma lutein concentrations between 0 and 24 hours post lutein consumption.

Time frame: Study visit 1 (24 hours), Study visit 2 (24 hours), study visit 3 (24 hours)

Secondary Outcomes

Plasma lutein maximum concentration

Maximum concentration of plasma lutein reached over 24 hours of measurement, and time point of maximum concentration.

Time frame: Study visit 1 (24 hours), Study visit 2 (24 hours), study visit 3 (24 hours)

Macular pigment optical density

Machine: measured by the Macular Pigment Screener II (Elektron Eye Technology). The non-invasive test uses heterochromatic flicker photometry. One measure completed at each study visit (3 study visits total).

Time frame: Study visit day 1, day 8, day 15

Daily dietary lutein and zeaxanthin intake

Daily dietary intake of lutein and zeaxanthin (mg/day) as measured by a food frequency questionnaire.

Time frame: Study visit day 1

Daily dietary lutein and zeaxanthin intake

Daily dietary intake of lutein and zeaxanthin (mg/day) as measured by a food frequency questionnaire.

Time frame: Study visit day 1, day 8, day 15

Data from ClinicalTrials.gov

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