COVID-19 Infection and Epithelial Cell Markers

McMaster University235 enrolled

Overview

To assess if TSLP expression by airway epithelial cells following COVID-19 infection regulates viral load and disease severity.

The study aim is to determine the relationship between COVID-19 infection and epithelial cell expression of TSLP. Two cohorts will be used. Cohort One will include 100 hospitalized patients with Covid-19, and 100 hospitalized patients without Covid-19. Cohort 2 will include mild/moderate asthmatics and healthy controls with bio-banked biopsy material used from donors who have previously consented for samples to be used for future research.

Study Type

OBSERVATIONAL

Enrollment

235

Conditions

Asthma Covid19

Eligibility

Sex: ALLMin age: 18 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Age 18 years and above; * Able to give informed consent; * Clinically tested for SARS-CoV-2 (as completed by standard laboratory testing e.g. RT-PCR) and with a positive result and clinical features in keeping with COVID-19 illness. The control group will be patients with a negative RT-PCR COVID-19 test and without any clinical features to suggest COVID-19 illness. In addition, the control group should have NO known or current features of respiratory infection, COPD, asthma, interstitial lung disease, other respiratory inflammatory conditions or lung cancer. * Able to provide a breath sample (as based on clinical judgement). Exclusion Criteria: \- none

Locations (1)

McMaster Cardio-Respiratory Research Lab

Hamilton, Ontario, Canada

RECRUITING

Outcomes

Primary Outcomes

TSLP expression in nasal epithelium

Compare the level of TSLP expression in nasal epithelium in patients with and without COVID-19 infection

Time frame: Through study completion, an average of 1 year

Secondary Outcomes

TSLP expression in endobronchial biopsies

Epithelial cell expression (protein staining) of TSLP in endobronchial biopsy tissue of asthmatic patients versus normal controls.

Time frame: Baseline

IL-33 expression in endobronchial biopsies

Epithelial cell expression (protein staining) of IL-33 in endobronchial biopsy tissue of asthmatic patients versus normal controls.

Time frame: Baseline

ACE-2 receptor expression in endobronchial biopsies

Epithelial cell expression (protein staining) of ACE-2 receptor in endobronchial biopsy tissue of asthmatic patients versus normal controls.

Time frame: Baseline

Central Contacts

Gail Gauvreau, PhD

CONTACT

9055259140 gauvreau@mcmaster.ca

Data from ClinicalTrials.gov

This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.