Comparison of Non-invasive Methods of Lung Ventilation in Patients With Respiratory Failure After Cardiac Surgery

Petrovsky National Research Centre of Surgery90 enrolled

Overview

Comparison of the effectiveness of three methods of non-invasive ventilation in patients with mild and moderate respiratory failure in the early postoperative period after cardiac surgery

The study includes the comparison of the three methods of non-invasive ventilation: non-invasive mask ventilation, high-flow oxygen therapy through a nasal cannula (high-flow nasal oxygenation) and non-invasive ventilation with a helmet in patients with mild and moderate respiratory failure in the early postoperative period after cardiac surgery. It assumes 90 randomized patients:30 patients in three study groups male and female aged 30 to 60 years of age inclusive, with mild or moderate respiratory failure.The study will be randomized, single-center, prospective.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

NONE

Enrollment

Conditions

Respiratory Failure

Interventions

Using of non-invasive mask ventilation, high-flow oxygen therapy through a nasal cannula (high-flow nasal oxygenation) and non-invasive ventilation with a helmetPROCEDURE

Using of non-invasive mask ventilation, high-flow oxygen therapy through a nasal cannula (high-flow nasal oxygenation) and non-invasive ventilation with a helmet for tackling the problem of respiratory failure

Eligibility

Sex: ALLMin age: 30 YearsMax age: 60 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: 1. Age from 30 years to 60 years inclusive 2. Decreased oxygenation function of the lungs (SpO2 less than 90%, PaO2/FiO2 less than 300, BH less than 25 per minute) 3. By data CT/x-ray examination of hypoventilation zones (pneumonia, atelectasis) 4. Consent the patient to participate in this study Exclusion Criteria: 1. Tracheal intubation, absence of independent breathing 2. Unstable hemodynamics or hemodynamically significant rhythm disturbances 3. Acute violation of the cerebral blood supply 4. Shocks of various etiologies 5. Impossibility provide respiratory protection , high risk of aspiration 6. Lack of productive contact with the patient 7. Patient's refusal to participate in this study

Locations (1)

Petrovsky Research National Centre of Surgery

Moscow, Russia

Outcomes

Primary Outcomes

PaO2/FiO2 more than 300

Comparison of PaO2/FiO2 before/after research

Time frame: hospitalisation period, an average of 1 week

Secondary Outcomes

arterial blood oxygenation level

Comparison arterial blood oxygenation level before/after research

Time frame: hospitalisation period, an average of 1 week

maximum inspiratory volume

Comparison maximum inspiratory volume before/after research

Time frame: hospitalisation period, an average of 1 week

Data from ClinicalTrials.gov

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