The aim of the present study is to determine the effect of non-nutritive sweeteners on intestinal barrier function and inflammatory markers in healthy subjects in comparison to mono- and disaccharides.
In the intervention study normal weight participants will receive beverages sweetened with non-nutritive sweeteners, mono- and disaccharides for a defined number of days. Before and after intervention parameters of intestinal barrier function will be assessed.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
BASIC_SCIENCE
Masking
SINGLE
Enrollment
18
Participants receive a beverage with a defined amount of non-nutritive sweetener.
Participants receive a beverage with a defined amount of non-nutritive sweetener and maltodextrin.
Participants receive a beverage with a defined amount of monosaccharide.
University of Vienna
Vienna, Austria
Changes in parameters of intestinal barrier function.
Changes in plasma endotoxin levels.
Time frame: 1 week
Changes in inflammatory markers.
Changes in IL-6 plasma levels (ng/ml).
Time frame: 1 week
Changes in blood pressure.
Changes in systolic and diastolic blood pressure
Time frame: 1 week
Changes in markers for glucose metabolism.
Changes in fasting glucose (mg/dl) and fasting insulin levels (mU/l)
Time frame: 1 week
Changes in markers for glucose metabolism.
Changes in fasting insulin levels (mU/l).
Time frame: 1 week
Changes in blood lipid levels.
Changes in triglyceride levels.
Time frame: 1 week
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Participants receive a beverage with a defined amount of disaccharide.