The main aim of this study is to determine the effect of a nootropic on cognitive performance (i.e., reaction time, inhibitory control, cognitive flexibility, working memory, neuro-psychological outcomes).
Cognitive decline is a worrisome consequence of normal or pathologic ageing, having a high personal, eco- nomic and societal burden; also, it could herald the onset of dementia which is associated with significant morbidity and mortality. However, with a general increase in life expectancy and a corresponding increase in the prevalence of age-related cognitive impairment, there have been concerted efforts towards the development and adoption of preventive strategies that would minimize the risk of developing dementia, or reduce the rate of cognitive decline with ageing. In the last few decades, certain compounds have been found useful in the management of cognitive decline. The term 'nootropic' has been used to define such substances with the capacity to enhance cognition. While research has led to the synthesis of several drugs with nootropic effects, attention is now being shifted to the discovery, characterization and utilization of nootropics from natural sources for the prevention and management of age-related cognitive decline. 25 young adults will be randomized into two conditions (nootropic and placebo conditions) with 48 hours of separation between conditions. 48h previous to the randomization the participants will perform a familiarization to avoid the learning effects. Each evaluation day will conform to the following tests: * Simple and multiple reaction time * Inhibitory control * Cognitive flexibility * Working memory * Creative intelligence * Verbal fluidity * Motivation * Mood * Positive and negative emotions * Adverse effects
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
OTHER
Masking
QUADRUPLE
Enrollment
25
10g of Evo-Gamers® lemon flavor (HSN®). The nutritional composition per service is: L-Tyrosine (1000mg), Acetyl L-Carnitine HCL (500mg), Citicoline sodium (200mg), L-alpha-Glycerylphosphorylcholine (Alpha-GPC; 100mg), Vitamin C (150mg), Vitamin E (12.1mg), Vitamin B6 (3mg), Vitamin B2 (3mg), Vitamin A (810μg), Vitamin D (10μg), Vitamin B12 (5μg), Taurine (500mg), Caffeine (300mg), L-Theanine (150mg), Mango Leaves (2000mg), Huperzia Leaves (200mg). The dose to be administered is that recommended on the labeling and nutritional information of the nootropic which has been produced under GMP procedures and approved by the EFSA.
10g of maltodextrin lemon flavor (HSN®).
Jonatan Ruiz Ruiz
Granada, Spain
Simple and multiple reaction time
Vienna Test System®
Time frame: 1.5 hours
Inhibitory control
Stroop test, E-Prime® software
Time frame: 1.5 hours
Working Memory
Tests Flankers and Task switching, EPrime ® software
Time frame: 1.5 hours
Working memory
N-Back y Spatial working memory , EPrime ® software
Time frame: 1.5 hours
Creative Intelligence
CREA test
Time frame: 1.5 hours
Verbal fluidity
Phonological and semantic verbal fluidity
Time frame: 1.5 hours
Motivation
Situational Motivation Scale (EMSI)
Time frame: 1.5 hours
Mood
EVEA scale
Time frame: 1.5 hours
Positive and negative emotions
PANAS scale
Time frame: 1.5 hours
Adverse effects
Visual analogue scales of adverse effects (gastrointestinal, nervous or psychologic)
This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.
Time frame: 1.5 hours