a Study of SHR1210 in Combination With Paclitaxel-albumin and Carboplatin in Extensive Stage Small Cell Lung Cancer

Inclusion Criteria: * 18 to 75 years old * Confirmed diagnosis of Extensive small cell lung cancer * Eastern Cooperative Oncology Group performance status (PS) of 0 to 1 * The function of vital organs meets the following requirements. WBC ≥ 3.0 × 10\^9/L, ANC≥1.5×10\^9/L, PLT≥100×10\^9/L, Hb≥9g/dL, ALT and AST ≤2.5 times ULN, TBIL ≤1.5 x ULN, CREA ≤1.5 x ULN or CCr≥50mL/min. INR≤1.5 x ULN, APTT ≤1.5 x ULN * have not received first-line systemic therapy or immunosuppressive therapy for es-sclc * The estimated survival period is more than 8 weeks * The subjects voluntarily joined the study, signed informed consent, Exclusion Criteria: * Active or untreated CNS metastases were detected by computed tomography (CT) or magnetic resonance imaging (MRI); * Leptomeningeal diseases * Uncontrolled or symptomatic hypercalcemia * Active, known or suspected autoimmune diseases * have received any T cell co stimulation or immune checkpoint therapy * Corticosteroids (\> 10 mg / day prednisone or equivalent) or other immunosuppressants were used within 14 days before the first dose of study drug * Subjects had active infections * Patients who have previously received allogeneic bone marrow transplantation or solid organ transplantation * Known to be allergic to the study drug or excipients, known to have a serious allergic reaction to any kind of monoclonal antibody; have a history of hypersensitivity to Paclitaxel-albumin or Carboplatin * According to the researcher's judgment, there are other factors that may lead to the termination of the study