Effect of the Consumption of Alcohol-free Beers With Different Carbohydrates Composition on Postprandial Metabolic Response

Universidad de Zaragoza30 enrolled

Overview

The overall objective of this study is to explore the glycemic index and glycemic load induced by an alcohol-free beer with modified composition (including almost full fermentation of carbohydrates and the addition of isomaltulose and a resistant maltodextrin), as well as its postprandial metabolic response, compared to the effect induced by: a) an alcohol-free beer with a usual composition; b) an alcohol-free beer with modified composition (including almost full fermentation of carbohydrates and the addition of a resistant maltodextrin). This study includes two cross-over sub-studies recruiting healthy participants. In the first one, 10 healthy volunteers receive 25 g of carbohydrates coming from: regular alcohol-free beer (RB), alcohol-free beer with almost completely eliminated maltose and enriched with isomaltulose (2.5 g/100 mL) and a resistant maltodextrin (0.8 g/100 mL) (IMB), alcohol-free beer with the same maltose removal enriched with resistant maltodextrin (2.0 g/100 mL) (MB) and glucose solution. In the second study, 20 healthy volunteers are provided with 50 g of carbohydrates from white bread and water and the same meal plus 14.3 g of carbohydrates coming from: RB, IMB, MB and extra white bread. Blood is sampled at baseline and for 2 h, every 15 min, after ingestion.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

PREVENTION

Masking

DOUBLE

Enrollment

Conditions

Healthy Diet Postprandial Hyperglycemia

Interventions

Sub-study 1OTHER

Subjects were provided with: a) Glucose beverage; b) Regular alcohol-free beer; c) Alcohol-free beer with modified composition (isomaltulose + maltodextrin); d) Alcohol-free beer with modified composition (++ maltodextrin).

Sub-study 2OTHER

Subjects were provided with: a) White bread + Water; b) White bread + Regular alcohol-free beer; c) White bread+Alcohol-free beer enriched with isomaltulose+maltodextrin); d) White bread + Alcohol-free beer enriched with ++ maltodextrin; e) Extra-White bread + Water.

Eligibility

Sex: ALLMin age: 18 YearsMax age: 80 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * BMI between 18.5 and 27.5 kg/m2. Exclusion Criteria: * Presence of cardiometabolic pathology such as dyslipemia (total cholesterol \> 200 mg/dL and/or triglycerides \> 150 mg/dL, and/or taking lipid-lowering drugs), prediabetes or type 1 or 2 diabetes mellitus (glucose ≥ 100 mg/dL and/or glycosylated hemoglobin ≥ 5.7% and/or taking hypoglycemic drugs) or high blood pressure without drug treatment. * Presence of other chronic pathologies that could interfere with the results of the study such as cardiovascular disease, kidney disease, thyroid disease or liver disease. * Presence of intestinal malabsorption syndromes and/or presence of Chron disease or ulcerative colitis. * Use of drugs that may interfere with lipid and/or glycidic metabolism. * Presence of some analytical alteration that could interfere with the results of the study. * Increased or decreased body weight of ≥ 5 kg in the last 6 months. * Gluten intolerance. * Regular intake of functional foods such as phytosterols or red rice yeast, which have a significant effect on lipid or glycidic metabolism, in the last 6 weeks. * Intake of vitamin supplements. * Hormone replacement therapy.

Locations (1)

Instituto de Investigación Sanitaria Aragón, Hospital Universitario Miguel Servet, Universidad de Zaragoza

Zaragoza, Spain

Outcomes

Primary Outcomes

Glucose

Time frame: Change from Baseline to 15-minutes after consumption of the beverage.

Glucose

Time frame: Change from Baseline to 30-minutes after consumption of the beverage.

Glucose

Time frame: Change from Baseline to 45-minutes after consumption of the beverage.

Glucose

Time frame: Change from Baseline to 60-minutes after consumption of the beverage.

Glucose

Time frame: Change from Baseline to 75-minutes after consumption of the beverage.

Glucose

Time frame: Change from Baseline to 90-minutes after consumption of the beverage.

Glucose

Time frame: Change from Baseline to 105-minutes after consumption of the beverage.

Glucose

Time frame: Change from Baseline to 120-minutes after consumption of the beverage.

Insulin

Time frame: Change from Baseline to 15-minutes after consumption of the beverage.

Insulin

Time frame: Change from Baseline to 30-minutes after consumption of the beverage.

Insulin

Time frame: Change from Baseline to 45-minutes after consumption of the beverage.

Insulin

Time frame: Change from Baseline to 60-minutes after consumption of the beverage.

Insulin

Time frame: Change from Baseline to 75-minutes after consumption of the beverage.

Insulin

Time frame: Change from Baseline to 90-minutes after consumption of the beverage.

Insulin

Time frame: Change from Baseline to 105-minutes after consumption of the beverage.

Insulin

Time frame: Change from Baseline to 120-minutes after consumption of the beverage.

GLP-1

Time frame: Change from Baseline to 15-minutes after consumption of the beverage.

GLP-1

Time frame: Change from Baseline to 30-minutes after consumption of the beverage.

GLP-1

Time frame: Change from Baseline to 45-minutes after consumption of the beverage.

GLP-1

Time frame: Change from Baseline to 60-minutes after consumption of the beverage.

GLP-1

Time frame: Change from Baseline to 75-minutes after consumption of the beverage.

GLP-1

Time frame: Change from Baseline to 90-minutes after consumption of the beverage.

GLP-1

Time frame: Change from Baseline to 105-minutes after consumption of the beverage.

GLP-1

Time frame: Change from Baseline to 120-minutes after consumption of the beverage.

GIP

Time frame: Change from Baseline to 15-minutes after consumption of the beverage.

GIP

Time frame: Change from Baseline to 30-minutes after consumption of the beverage.

GIP

Time frame: Change from Baseline to 45-minutes after consumption of the beverage.

GIP

Time frame: Change from Baseline to 60-minutes after consumption of the beverage.

GIP

Time frame: Change from Baseline to 75-minutes after consumption of the beverage.

GIP

Time frame: Change from Baseline to 90-minutes after consumption of the beverage.

GIP

Time frame: Change from Baseline to 105-minutes after consumption of the beverage.

GIP

Time frame: Change from Baseline to 120-minutes after consumption of the beverage.

Secondary Outcomes

Leptin

Time frame: Change from Baseline to 60-minutes after consumption of the beverage.

Leptin

Time frame: Change from Baseline to 120-minutes after consumption of the beverage.

Glucagon

Time frame: Change from Baseline to 60-minutes after consumption of the beverage.

Glucagon

Time frame: Change from Baseline to 120-minutes after consumption of the beverage.

Ghrelin

Time frame: Change from Baseline to 60-minutes after consumption of the beverage.

Ghrelin

Time frame: Change from Baseline to 120-minutes after consumption of the beverage.

Polypeptide Y

Time frame: Change from Baseline to 60-minutes after consumption of the beverage.

Polypeptide Y

Time frame: Change from Baseline to 120-minutes after consumption of the beverage.

Pancreatic polypeptide

Time frame: Change from Baseline to 60-minutes after consumption of the beverage.

Pancreatic polypeptide

Time frame: Change from Baseline to 120-minutes after consumption of the beverage.

HDL cholesterol

Time frame: Change from Baseline to 60-minutes after consumption of the beverage.

HDL cholesterol

Time frame: Change from Baseline to 120-minutes after consumption of the beverage.

Data from ClinicalTrials.gov

This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.

LDL cholesterol

Time frame: Change from Baseline to 60-minutes after consumption of the beverage.

LDL cholesterol

Time frame: Change from Baseline to 120-minutes after consumption of the beverage.

Triglycerides

Time frame: Change from Baseline to 60-minutes after consumption of the beverage.

Triglycerides

Time frame: Change from Baseline to 120-minutes after consumption of the beverage.