Assessment of Neural Oscillations in Adult Subjects With Down Syndrome and Typically Developing Subjects in Resting State and While Conducting Cognitive Tasks

Common Inclusion Criteria: * Weight ≥ 50 kg and ≤ 100 kg * Body mass index (BMI) ≥ 18.5 and ≤ 30 TD group additional Inclusion Criteria: * Abstinence for alcohol 72h prior to the screening * Able to read Spanish and adhere to study requirements. * Signed informed consent prior to any study-mandated procedure. DS group additional Inclusion Criteria: * Clinical diagnosis of Down syndrome (full trisomy 21 and translocations) documented by chromosomal analysis (karyotyping). * Subject understands and accepts the trial procedures. * Subject assenting and/or willing to participate. * Signed informed consent by subject and legal representative prior to any study-mandated procedure. * Subject independently mobile and have sufficient vision and hearing to participate in study evaluations. * Abstinence for alcohol 72h prior to the screening. * Clinical Evaluation of Language Fundamentals Preschool-2 (CELF Preschool-2) test score ≥ 7. * Subjects must have a parent, or other reliable caregiver who agrees to accompany the subject to all clinic visits, provide information about the subject as required by the protocol, and ensure compliance with study tests. * Subjects are expected to complete all procedures scheduled during the study visits. They must be able to be understood most of the time and must not use other forms of communication, signs, symbol boards or devices as their primary form of communication. TD group Exclusion Criteria: * Substance use disorders except for mild alcohol use disorder and/or mild or moderate nicotine use disorder. * Testing positive for drugs of abuse in urine at screening or the observation day. * Lifetime clinically significant cardiovascular, renal, pulmonary, hepatic, onco-hematological, endocrine, gastrointestinal, mental or neurological disease. * Any other diseases or conditions that in the judgment of the investigator would interfere with the subject's ability to comply with study procedures or requirements and/or study results interpretation. * Any clinically significant findings in physical examination including vital signs. * Any prescription or over the counter drug (except occasional use of paracetamol) in the last 2 weeks before Day 1 of each period. * Patient included in a clinical study with drugs in the last three months. DS group Exclusion Criteria: * Mosaic Down syndrome * Personal history of infantile spasms/convulsions/epilepsy, severe head trauma or central nervous system infections (e.g. meningitis), with the exception of a single isolated febrile seizure. * Subjects with a current Diagnostic of autism spectrum disorder or any primary psychiatric diagnosis. Diagnoses that are secondary, such as attention deficit hyperactivity disorder, depressive disorders and conduct disorders are allowed as long as they are considered to not interfere with study conduct and are stable during the 3 months preceding randomization. Related allowed treatments must be on stable dosing for the last 3 months. * Symptoms of early dementia as assessed by the Dementia Screening Questionnaire for Individuals with Intellectual Disabilities. * Substance use disorder according to the Diagnostic and Statistical Manual of Mental Disorders (DSM-5) criteria. * Positive urine test for drugs of abuse or alcohol breath test at screening and prior to dosing. * Epileptiform abnormalities (excluding isolated sharp waves and beyond those expected for age) in 10 min EEG. * Any life-threatening disease. * Any other clinically relevant concomitant disease or condition or finding at screening that in the judgment of the investigator could interfere with, the treatment thereof might interfere with, the conduct of the study and related procedures and/or might bias the study results interpretation, or could jeopardize the subject's safety. * Neuroleptic drugs within 3 months prior to randomization. * Any clinically significant findings in physical examination including vital signs. * Any new prescription or over the counter drug (except occasional use of paracetamol) in the last 2 weeks before Day 1 of each period. * Testing positive for drugs of abuse in urine at screening or the observation day * Patient included in a clinical study with drugs in the last three months.