We aim to analyze the impact of a single acute exercise intervention (ergometry) on the expression pattern of specific heart health related miRNAs in healthy, previously sedentary participants, and how this pattern will be changed after 4 months of increasing the weekly physical activity \>150 minutes.
Exercise induced changes in heat health related miRNA expression pattern are analyzed in plasma samples collected at rest and immediately after the completion of an all-out ergo spirometry test, conducted during the baseline examination. Additionally participants will perform a pulse wave analysis to evaluate their arterial stiffness, a bioimpedanzanalysis to evaluate their body composition, blood lipids will be measured as well as their exercise capacity. After the baseline examination, all participants will perform once per week a supervised endurance and strength training at our facility. In addition, the participants will be provided with a digital application for planning and documentation of their home based physical activity. Together with an expert, they plan their weekly physical activities so that they reach 150 min of physical activity each week over a period of 4 months. After this training/exercise intervention all participants will perform all measurements from the baseline examination again.
Study Type
INTERVENTIONAL
Allocation
NA
Purpose
BASIC_SCIENCE
Masking
NONE
Enrollment
46
Participates perform once a week for 4 months an in-house supervised endurance and strength training.
Participants are provided with an application for planning and documentation of their physical activity, together with an expert participants plan their physical activities for their home-based training to reach at least 150 min physical activity per week.
Department of Sports Medicine, Prevention and Rehabilitation Paracelsus Medical University
Salzburg, Austria
miRNA expression response to acute all-out exercise (ergometry)
expression change of miRNA due to all-out ergometry at baseline
Time frame: Baseline
Change from baseline miRNA expression at 4 months
4 months of exercise intervention in healthy previously sedentary participants leads to exercise-induced changes in the cardio protective miRNA expression profiles
Time frame: after 4 months of exercise intervention
Change from baseline in miRNA expression response to acute all-out exercise (ergometry) at 4 months
4 months of exercise intervention in healthy previously sedentary participants leads to a change in the acute exercise response (all-out ergometry).
Time frame: after 4 months of exercise intervention
Heart rate
Heart rate will be measured by graded exercise testing on cycle ergometer.
Time frame: Before and after 4 months of exercise intervention
blood lipides
blood lipides will be measured before and after intervention
Time frame: Before and after 4 months of exercise intervention
arterial stiffness
arterial stiffness will be measured before and after intervention
Time frame: Before and after 4 months of exercise intervention
body composition
body composition will be measured before and after intervention
Time frame: Before and after 4 months of exercise intervention
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exercise capacity
exercise capacity will be measured by graded exercise testing on cycle ergometer.
Time frame: Before and after 4 months of exercise intervention
body weight
body weight will be measured before and after intervention
Time frame: Before and after 4 months of exercise intervention
digital application
user feedback and user experience will be evaluated after the intervention
Time frame: 4 months of exercise intervention