Cross-sectional study. We will prospectively obtain ddcf-DNA levels in all patients who undergo routine coronary angiography \> 1 year after HT. Our main goal is to evaluate the performance of Donor-derived Cell Free DNA (ddcf-DNA) as a biomarker of CAV.
Study Type
OBSERVATIONAL
Enrollment
94
We will compare ddcfDNA with coronary angiogram determined CAV grading, according to ISHTL2010 classification
University Hospital Puerta de Hierro
Majadahonda, Madrid, Spain
Correlation between ddcf-DNA and CAV
Correlation between ddcf-DNA levels and the presence of any degree of CAV (CAV0 vs CAV1, 2, or 3)
Time frame: 2 years
Performance of the biomarker for the diagnosis of CAV
Determine the performance of this biomarker in this situation using receiver-operator characteristics analysis.
Time frame: 2 years
Correlation of ddcf-DNA with the different degrees of CAV (0, 1, 2 and 3)
Correlation of ddcf-DNA with the different degrees of CAV (0, 1, 2 and 3)
Time frame: 2 years
Correlation of ddcf-DNA with other biomarkers (NTproBNP and troponin I)
Correlation of ddcf-DNA with other biomarkers (NTproBNP and troponin I)
Time frame: 2 years
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