Multiparametric magnetic resonance imaging (mpMRI) is now widely used to risk stratify men with a suspicion of prostate cancer and identify suspicious regions for biopsy. Advanced MRI techniques have emerged which seek to improve this characterisation and could predict biopsy results non-invasively before men undergo biopsy. Before these techniques are translated clinically, robust histological and clinical validation is required. This study aims to clinically validate advanced MRI techniques in a cohort of men suspected with prostate cancer. Histological analysis of men undergoing biopsy, +/- prostatectomy will be used for biological validation of VERDICT; Vascular and Extracellular Restricted Diffusion for Cytometry in Tumours and Luminal Water imaging (LWI). In particular, prostatectomy specimens will be processed using 3-D printed patient-specific moulds to allow for accurate MRI and histology mapping.
Study Type
OBSERVATIONAL
Enrollment
300
Advanced Diffusion Model
Advanced T2 mapping
University College London Hospital
London, United Kingdom
RECRUITINGDiagnostic accuracy of VERDICT MRI
Quantitative assessment of VERDICT MRI reduces false positives by 10% compared to standard MRI alone
Time frame: 2 years
Diagnostic accuracy of Luminal Water Imaging (LWI)
Quantitative assessment of LWI reduces false positives by 10% compared to standard MRI alone
Time frame: 2 years
The proportions of true positives with index tests is the same as mpMRI.
Time frame: 2 years
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