Pharmacokinetic and Pharmacodynamic Study of a Novel Sublingual Aspirin Tablet

Inclusion Criteria: 1. Male, 18 to 55 years of age 2. Body mass index between 18-27kg/m2 3. Accessible vein for blood sampling 4. High probability for compliance and completion of the study 5. No significant abnormalities in general physical examination 6. Subjects must agree to take effective contraceptive methods to prevent his partner pregnant during the time of first dose of study medication until one week of last dose administration Exclusion Criteria: 1. History of hepatic, renal, biliary, cardiovascular, gastrointestinal, haematological and other chronic and acute diseases within 3 months prior to screening 2. Clinically relevant abnormality in physical examination, ECG evaluation, urine test, blood chemistry or haematological test at the discretion of the investigator 3. Positive results for hepatitis B at screening 4. Moderate smoker (on average more than 2 cigarettes a day within 1 month prior to the start of first dosing) 5. Moderate consumption of alcohol (on average more than one drink per day within 1 month prior to start of first dosing) 6. Blood donation of more than 350 ml within 4 weeks prior to start of first drug dosing 7. Treatment of aspirin within 4 weeks before first dosing 8. Volunteer in any other clinical drug study within 2 months prior to start of first dosing 9. Hypersensitivity to aspirin or other drug in its class