Is Involucrin Has a Role in Verruca Vulgaris? A Clinical and Immunohistochemical Study

Benha University60 enrolled

Overview

Vitamin D3 plays important role in keratinocyte differentiation and had been used recently in verruca vulgaris. Aim of the work: To assess the expression of involucrin in verrucae vulgaris before and after injection of vitamin D3. Subjects and Methods: This study included 60 patients with verrucae vulgaris subjected to intralesional injection of vitamin D3 at three weeks interval for a maximum of five sessions. Immunohistochemical assessment of involucrin was done before and after injection and compared to skin biopsies from 30 healthy individuals

Study Type

INTERVENTIONAL

Allocation

Purpose

TREATMENT

Masking

NONE

Enrollment

Conditions

Verruca Vulgaris Involucrin

Interventions

CholecalciferolDRUG

Cholecalciferol injection

Eligibility

Sex: ALLMin age: 18 YearsMax age: 45 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion criteria: Patients with multiple verruca vulgaris Patients with with verrucae vulgaris with size more than 3 cm Exclusion Criteria: Patients with a past history of allergic response to vitamin D. Pregnant or lactating females. Hepatic patients. Renal patients. Patients with bleeding tendency.

Locations (1)

Essam Mohamed El-sayed Akl

Banhā, Egypt

Outcomes

Primary Outcomes

Resolution of verrucae

Decrease of verrucae size Decrease of verrucae number

Time frame: 3 months

Secondary Outcomes

Involucrin expression

Change of expression pattern of involucrin by immunohistochemical study Change of expression grade of involucrin by immunohistochemical study

Time frame: 3 months

Data from ClinicalTrials.gov

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