A Clinical Trial to Evaluate the Safety and Immunogenicity of rVSV∆G-LASV-GPC Vaccine in Adults in Good General Heath

Inclusion Criteria 1. Adults in good general health as assessed by medical history, physical examination, and laboratory tests 2. At least 18 years of age on the day of screening and has not reached his/her 51st birthday on the day of vaccination 3. Willing to comply with the requirements of the protocol and available for follow-up for the planned duration of the study 4. Willing to undergo HIV testing, risk reduction counselling, and receive HIV test results 5. Use effective method of contraception 6. Understand the study and provide written informed consent Exclusion Criteria 1. Confirmed HIV-1 or HIV-2 infection 2. Any clinically relevant abnormality on history or examination including history of immunodeficiency or autoimmune disease 3. Any clinically significant chronic medical condition that, in the opinion of the Investigator, makes the participant unsuitable for participation in the study 4. Pregnant or lactating 5. Bleeding disorder that was diagnosed by a physician 6. Prior receipt of another investigational Lassa vaccine candidate 7. Receipt of blood transfusion or blood-derived products within the previous 3 months 8. Prior exposure to LASV as documented by history 9. History of severe local or systemic reactogenicity to any vaccine 10. Body mass index (BMI) ≥35 11. Mild or greater hearing impairment defined as ≥26dB loss in either ear