Adductor Canal Block Versus Patient Controlled Analgesia, in the Surgical Stress Response for Anterior Cruciate Ligament Repair

Pontificia Universidad Catolica de Chile

Overview

To evaluate the surgical stress response in anterior cruciate ligament repair with an adductor canal block versus patient controlled endovenous analgesia.

Preoperative, 2 hours and 24 hours stress biomarkers will be evaluated in two groups of patients, continous adductor canal block and morphine patient controlled endovenous analgesia.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

NONE

Conditions

Anesthesia Stress, Physiological Surgery

Interventions

Adductor Canal BlockPROCEDURE

Continous peripheral nerve block

Morphine Patient Controlled AnalgesiaDEVICE

Morphine Patient Controlled Analgesia Delivery System

Eligibility

Sex: MALEMin age: 18 YearsMax age: 65 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Male, * 18-65 years, * traumatic Anterior Cruciate Ligament tear, scheduled for elective arthroscopic repair with Semitendinous-Gracillis technique at first time in the morning, with full articular range, * no other traumatologic lesions. Exclusion Criteria: * denied consent to participate, * chronic steroids user, * diabetes type 1 or 2, * insulin resistance, * concurrent infectious disease, * cognitive failure, coagulopathy, * allergy to study drugs, * surgery scheduled in the afternoon

Locations (1)

Pontificia Universidad Católica de Chile

Santiago, Chile

Outcomes

Primary Outcomes

Change of Blood Cortisol from baseline to 24 hours

Blood Cortisol will be evaluated preoperatively, 2 hours and 24 hours postoperatively.

Time frame: 24 hours

Secondary Outcomes

Change of C Reactive Protein from baseline to 24 hours

C Reactive Protein will be evaluated preoperatively, 2 hours and 24 hours postoperatively.

Time frame: 24 hours

Change of Glycemia from baseline to 24 hours

Glycemia will be evaluated preoperatively, 2 hours and 24 hours postoperatively.

Time frame: 24 hours

Data from ClinicalTrials.gov

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