Role of Toilet Bronchoscopy in RICU

Assiut University130 enrolled

Overview

Toilet bronchoscopy is a potentially therapeutic intervention to aspirate retained secretions within the endotracheal tube and airways and revert atelectasis. Aspiration of airway secretions is the most common indication to perform a therapeutic bronchoscopy in the intensive care unit (ICU) . Toilet bronchoscopy is particularly beneficial when retained secretions are visible during the procedure and when air-bronchograms are not present at the chest radiograph. It is also beneficial when there is an indication to reverse lobar atelectasis, rather than simply to remove accumulated mucus. Toilet bronchoscopy is used in lobar and complete lung collapse in mechanically ventilated patients who fail to respond to treatments such as physiotherapy or recruitment manoeuvres. The success rates (defined as radiographic improvement on chest X-ray \[CXR\] or an improved PaO2/PAO2 ratio) in the ICU patient population had. Patients with acute hypoxaemic respiratory failure may already be on non-invasive ventilation (NIV), or require NIV preemptively for Fiberoptic Bronchoscopy (FB). These patients should be considered high risk for requiring intubation post-procedure; therefore, Fiberoptic Bronchoscopy should be performed by an experienced operator in a setting allowing facilities to safely secure the airways. NIV with early therapeutic FB rather than mechanical ventilation can help avoid intubation and reduce tracheostomy rate. Hospital mortality, duration of ventilation, and hospital stay remain similar

Aim Of Work To study the value of toilet bronchoscopy in 1. Mechanical ventilated patients with chest disease and copious secretion. 2. Mechanical ventilated patients diagnosed to have atelectasis radiologically. 3. Patients on non-invasive ventilation with chest diseases and copious secretion 4. Compare Different types of mucolytics during toilet bronchoscopy in mechanically ventilated patients. 5. Compare Different types of sedations during toilet bronchoscopy in mechanically ventilated patients.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

SUPPORTIVE_CARE

Masking

Interventions

toilet bronchoscopePROCEDURE

Toilet bronchoscopy will be done by infuse normal saline or N-Acetylcysteine with a syringe, observing the flow of saline at the distal tip of the bronchoscope then suction intra bronchial visible secretions during the procedure and also suction of specific lobe guided by radiological finding in the patient A chest X-ray will be routinely performed prior and after the procedure, HRCT is mandatory when chest x-ray not clearly defining the collapse monitoring of heart rate, oxygen saturation, ventilator parameters, and arterial blood pressure will be done

Eligibility

Sex: ALLMin age: 18 YearsMax age: 80 Years

Medical Language ↔ Plain English

Inclusion Criteria: * • Patients on mechanical ventilation with underlying dieases that are characterized with mucus overproduction such as asthma, chronic obstructive pulmonary disease (COPD), bronchiectasis, and cystic fibrosis. * Patients on mechanical ventilation with visible large amount of sputum during suction in order to clear secretions. * Patients on mechanical ventilation with radiologically diagnosed atelectasis and absent air-bronchograms * Patient on NIV who was benefit from toilet bronchoscopy to clear retained secretion. Exclusion Criteria:Absolute contraindications * Absence of consent from the patient or his/her representative. * Inability to adequately oxygenate the patient during the procedure. * Current myocardial ischaemia. * Significant haemodynamic instability. * Life-threatening cardiac arrhythmias. * Current significant bronchospasm. * Undrained pneumothorax. Relative contraindications * Thrombocytopenia (platelet count ≤50,000 platelets/mm). * INR of 2 or greater, or an elevated PTT. * BUN \>30. * severe tracheal obstruction. * Recent myocardial ischaemia and/or unstable angina. * Intracranial hypertension. * Poorly-controlled heart failure. * Recent oral intake.

Outcomes

Primary Outcomes

1- percent of patients develop radiological improvement

assessed improvement of atelectasis by chest x-ray or HRCT

Time frame: 12 months

2- improvement of hypoxemia

assessed by sao2/fio2 or pao2/fio2 before and after procedure

Time frame: 12months

3-Lung mechanics reduction post procedure in mechanical ventilated patients

resistance measured by cm H2o /Liter/ second

Time frame: 12 months

Lung mechanics improvement post procedure in mechanical ventilated patients

assessed by static compliance measured by ml/cm H2o

Time frame: 12 months

Secondary Outcomes

length of ICU stay

measured by days

Time frame: 12 months

length of hospital stay

measured by days

Time frame: 12 months

occurrence of complications

developed or not

Time frame: 12 months

4-Hospital mortality

percent in each group

Time frame: 12 months

Role of Toilet Bronchoscopy in RICU

Overview

Conditions

Interventions

Eligibility

Locations (1)

Outcomes

Primary Outcomes

Secondary Outcomes

Central Contacts