Investigation of the association between PaCO2 change after extra corporeal membrane oxygenation (ECMO) initiation and neurological outcome and mortality in neonates treated by ECMO for respiratory failure.
Retrospective analysis of the ELSO database investigating the association between the change of PCO2 value after ECMO start and the risk of acute neurological event under ECMO defined by the onset of cerebral bleeding and/or ischemic stroke and/or clinical or electrical seizure and/or brain death.
Study Type
OBSERVATIONAL
Enrollment
4,072
Neonates (\<28 j) supported by ECMO for severe respiratory failure
Nantes University Hospital
Nantes, Loire-Atlantique, France
Acute Neurological Event
Onset of cerebral bleeding and/or ischemic stroke and/or clinical or electrical seizure and/or brain death. The outcome (ANE) was defined by the occurrence of almost one of the following item: * Ischemic or hemmorrhagic stroke diagnosed by ultrasounds, CT or MRI * Clinical or electrical seizures : diagnosed by ElectroEncepahloGraphy (EEG) * Brain death clinically diagnosed
Time frame: Up to 90 days after ECMO initiation
28-day mortality
Newborns died after 28 days despite ECMO assistance
Time frame: 28 days after ECMO start
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