The Evaluation of Functional Parenchymal Volume and Split Renal Function Before and After Partial Nephrectomy

I.M. Sechenov First Moscow State Medical University60 enrolled

Overview

The study aims to compare pre- and postoperative 3D renal function results of patients who underwent on-clamp and off-clamp partial nephrectomy.

Study Type

INTERVENTIONAL

Allocation

NON_RANDOMIZED

Purpose

TREATMENT

Masking

NONE

Enrollment

Conditions

Renal Cell Carcinoma

Interventions

On-clamp partial nephrectomyPROCEDURE

Partial nephrectomy will performed with renal artery clamping (less than or equal to 25 minutes)

Off-clamp partial nephrectomyPROCEDURE

Partial nephrectomy will performed without renal artery clamping

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: 1\. Men and women \>18 years; 2. Diagnosis of unilateral renal cell carcinoma (stage T1-T3aN0M0); 3. Planned surgery: retroperitoneoscopic/laparoscopic/robotic partial nephrectomy; 4. Patients with CT of the kidneys with contrast enhancement performed according to the required protocol. \- Exclusion Criteria: 1. Age \< 18 years old or ASA\> 3; 2. Solitary kidney; 3. Bilateral kidney 4. The presence of concomitant systemic pathology (DM, AH), as well as kidney disease (glomerulonephritis), which can change the state of the renal parenchyma; 5. Obstructive nephropathy 6. Systemic intake of nephrotoxic drugs; 7. Pregnancy. -

Locations (1)

Sechenov University.

Moscow, Russia

RECRUITING

Outcomes

Primary Outcomes

GFR after the surgery

Time frame: 6 months

Secondary Outcomes

Complication rate (Clavien-Dindo)

Time frame: 3 months

Central Contacts

Dmitry Fiev, M.D., Ph.D.

CONTACT

+79265690949 fiev@mail.ru

Dmitry Enikeev, M.D., Ph.D.

CONTACT

Data from ClinicalTrials.gov

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