Assessment of the 90-day Mortality Risk Score After VATS Lobectomy

Università degli Studi dell'Insubria2,209 enrolled

Overview

A five classes (A-E) aggregate risk score predicting 90-day mortality after video-assisted thoracoscopic lobectomy for lung cancer, including as independent factors male sex (3 points), carbon monoxide lung diffusion capacity \<60% (1 point) and operative time \>150 minutes (1 point), has been recently published. This study aims to assess the effectiveness and reliability of this risk model in a large, independent cohort of patients, in order to confirm its generalizability.

From the Italian VATS Group Database, we selected patients who underwent video-assisted thoracoscopic lobectomy for non-small cell lung cancer. We calculated the aggregate risk score and the corresponding class of 90-day mortality risk for each patient. The correlation between risk classes and mortality rates was tested by Spearman's rho-test. Model calibration was evaluated by Hosmer-Lemeshow goodness-of-fit test.

Study Type

OBSERVATIONAL

Enrollment

2,209

Conditions

Lung Cancer Surgery--Complications Morality

Interventions

VATS lobectomyPROCEDURE

VATS lobectomy

Eligibility

Sex: ALL

Medical Language ↔ Plain English

Inclusion Criteria: \- Patients undergoing VATS lobectomy for non-small cell lung cancer Exclusion Criteria: * Incomplete data for risk score calculation * Tumor size \>5 cm * Follow-up \<3 months * Patients undergoing neoadjuvant treatment * Patients undergoing extended resection

Outcomes

Primary Outcomes

90-day postoperative mortality

Alive/Death (cause of death)

Time frame: 90 day post surgical procedure

Data from ClinicalTrials.gov

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