The Possible Effects of Roflumilast on Obesity Related Disorders

Inclusion Criteria: 1. Prediabetic patients (fasting blood glucose between 100 mg/dl and 125 mg/dl or HbA1C within the range 5.7% and 6.4%). 2. Obese subjects (BMI ≥30 kg/m2 and \<40 kg/m2). Exclusion Criteria: 1. Patients with morbid obesity (BMI \> 40 kg/m2). 2. Patients already on weight lowering agents or weight loss program. 3. History or current diagnosis of major depressive disorder or other psychiatric disorders that in the opinion of the investigator would make participation unsafe for the participant. 4. Moderate to severe liver disease (Child-Pugh B or C), renal disease, thyroid disease, cardiovascular disease, peripheral vascular disease or coagulopathy. 5. Women will be excluded from our study if they are pregnant, breastfeeding, currently on contraceptive pills or if they plan to become pregnant prior to the end of the study. 6. Patients on medications that can interfere with glucose or lipid metabolism (e.g. hypoglycemic agents, corticosteroids, anti-hyperlipidemics, non-selective β-blockers thiazides, etc.) and subjects with organic causes of obesity. 7. Diabetic patients and patients with any inflammatory disease. 8. Smokers. 9. Patients on cytochrome P450 inducers (e.g. rifampicin, phenobarbital, carbamazepine, phenytoin, etc.)