This is a single center patient registry of patients receiving a transjugular intrahepatic portosystemic shunt (TIPS) at Hannover Medical School. By collecting and analyzing clinical data as well as blood samples, the overall aim is to optimize TIPS therapy (e.g. specify selection criteria).
Study Type
OBSERVATIONAL
Enrollment
250
Patients are included in the registry if they receive a transjugular intrahepatic portosystemic shunt at Hannover Medical School and provide written informed consent.
Hannover Medical School
Hanover, Lower Saxony, Germany
RECRUITINGMortality
Patients who die within 1 year
Time frame: 1 year
Occurrence of (Minimal) Hepatic Encephalopathy
Using the Portosystemic encephalopathy (PSE) syndrome test, critical flicker frequency (CFF) and animal naming test (S-ANT)
Time frame: 1 year
Change in Nutritional Status
Nutritional Status will be measured by hand grip strength (dynamometer) in kg
Time frame: 1 year
Change in Quality of Life
Using the questionnaire short-form 36 (SF36) (Score range 0-100, higher scores correspond to better quality of life)
Time frame: 1 year
Change in inflammatory markers (e.g. cytokine)
Different cytokines and markers of bacterial translocation (e.g. LPS) are measured
Time frame: 12 months
Change in different metabolites using mass spectroscopy (metabolomics measurements)
More than 300 metabolites will be measured
Time frame: 12 months
Analysis of cellular immunity by collection of peripheral blood mononuclear cells (PBMCs)
Fluorescence activated cell sorting (FACS) analysis, genetics and in vitro stimulation assays will be performed
Time frame: 12 months
Analysis of stool samples
Analysis of the intestinal microbiome and metagenome analysis (shotgun sequencing)
This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.
Time frame: 12 months
Measurement of portal hypertension
Measurement of the hepatic venous pressure gradient (HVPG) to ensure the efficacy of the TIPS insertion
Time frame: 6 months